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Research Article
HLA antigens in multiple sclerosis of northern Spanish population.
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  1. C López-Larrea,
  2. D F Uría,
  3. E Coto
  1. Inmunología, Hospital NS Covadonga, Oviedo, Spain.

    Abstract

    HLA-A, -B, -C, -DR, -DQ antigens were studied in 43 multiple sclerosis (MS) patients with clinically definite remittent sclerosis from Asturias (North Spain). The prevalence of HLA-B7, B7 and B27 were significantly increased in MS. HLA-B35 was under-represented in these patients. DR2 was increased but not significantly. No association with DQw1 was discovered. The existence of several susceptibility factors in the more common B7/DR2/DQw1 haplotype is discussed.

    http://dx.doi.org/10.1136/jnnp.53.5.434

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