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Restless legs syndrome and nocturnal myoclonus: initial clinical manifestation of familial amyloid polyneuropathy.
  1. F Salvi,
  2. P Montagna,
  3. R Plasmati,
  4. G Rubboli,
  5. F Cirignotta,
  6. M Veilleux,
  7. E Lugaresi,
  8. C A Tassinari
  1. Institute of Neurology, University of Bologna, Italy.


    Restless legs syndrome was the first isolated clinical manifestation in four siblings of a family with familial amyloid polyneuropathy. Clinical and electrophysiological evidence of peripheral neuropathy appeared after a variable time interval. Polysomnography showed abnormal sleep patterns and nocturnal myoclonus in all patients. The restless legs syndrome responded favourably to clonazepam.

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