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Syncope or seizure? The diagnostic value of the EEG and hyperventilation test in transient loss of consciousness.
  1. W A Hoefnagels,
  2. G W Padberg,
  3. J Overweg,
  4. R A Roos,
  5. J G van Dijk,
  6. H A Kamphuisen
  1. Academic Hospital, Leiden, The Netherlands.


    In a prospective study of consecutive patients (age 15 or over) with transient loss of consciousness 45 patients had a history of seizure and 74 patients had a history of syncope. All patients had an EEG, ECG, laboratory tests and a hyperventilation test and were followed for an average of 14.5 months. Epileptiform activity in the interictal EEG had a sensitivity of 0.40 and a specificity of 0.95 for the diagnosis of a seizure. Epileptiform activity nearly doubled the probability of a seizure in doubtful cases. If no epileptiform activity was found, this probability remained substantially the same. The hyperventilation test had a sensitivity of 0.57 and a specificity of 0.84 for the diagnosis of syncope. A positive test increased the probability of syncope half as much in doubtful cases. A negative test did not exclude syncope. Laboratory tests were not helpful except for an ECG which was helpful in elderly patients.

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