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Neurofibrillary tangles in dementia pugilistica are ubiquitinated.
  1. G E Dale,
  2. P N Leigh,
  3. P Luthert,
  4. B H Anderton,
  5. G W Roberts
  1. Department of Immunology, St. George's Hospital Medical School, London, UK.


    Ubiquitin, a protein thought to be involved in the ATP-dependent non-lysosomal degradation of abnormal proteins, has already been identified as a component of neurofibrillary tangles in Alzheimer's disease. We have examined ubiquitin immunoreactivity in a unique collection of brains from 16 ex-boxers including 11 with dementia pugilistica. Neurofibrillary tangles of dementia pugilistica were labelled with an affinity purified antiserum to ubiquitin, and BF10, a monoclonal antibody to a neurofilament epitope.

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