You are here

  • Home
  • Archive
  • Volume 54, Issue 5
  • Immunological evidence for the co-existence of the Lambert-Eaton myasthenic syndrome and myasthenia gravis in two patients.

Article Text

Article menu
Download PDFPDF
Research Article
Immunological evidence for the co-existence of the Lambert-Eaton myasthenic syndrome and myasthenia gravis in two patients.
  1. J Newsom-Davis,
  2. K Leys,
  3. A Vincent,
  4. I Ferguson,
  5. G Modi,
  6. K Mills
  1. Department of Neurology, Radcliffe Infirmary, University of Oxford, UK.

    Abstract

    Two patients are described in whom a clinical and electromyographic diagnosis of the Lambert-Eaton myasthenic syndrome (LEMS) was made. Serum antibodies to voltage-gated calcium channels (VGCCs), the antigenic target in LEMS and to acetylcholine receptors (AChRs), the antigen in myasthenia gravis, were detected at raised titres in both cases, using radioimmunoassays based on 125I-omega-Conotoxin labelled VGCCs and 125I-alpha-Bungarotoxin labelled AChRs. These data provide immunological evidence for the coexistence of the two disorders in these patients.

    https://doi.org/10.1136/jnnp.54.5.452

    Statistics from Altmetric.com

      Request Permissions

      If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.