Article Text

Download PDFPDF

A prospective longitudinal study of depression, cognitive decline, and physical impairments in patients with Parkinson's disease.
  1. S E Starkstein,
  2. H S Mayberg,
  3. R Leiguarda,
  4. T J Preziosi,
  5. R G Robinson
  1. Department of Pscyhiatry, John Hopkins School of Medicine, Baltimore, MD 21205.


    A consecutive series of 105 patients with Parkinson's disease were examined for the presence of affective disorders, cognitive deficits, and impairments in activities of daily living (ADLs); 92 received the same evaluation 12 months after the initial examination. On the basis of the initial psychiatric findings, patients were divided into major, minor, and non-depressed groups. Patients with major depression showed a significantly greater cognitive decline, deterioration in ADLs, and further advance through the Hoehn and Yahr stages than patients with either minor depression or no depression.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.