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The use of botulinum toxin in the treatment of adductor spasmodic dysphonia.
  1. R Whurr,
  2. M Lorch,
  3. H Fontana,
  4. G Brookes,
  5. A Lees,
  6. C D Marsden
  1. National Hospital for Neurology and Neurosurgery, London.


    Botulinum toxin injections have been used to treat 31 patients with adductor spasmodic dysphonia. Injections of 3.00-3.75 units of botulinum toxin were performed bilaterally into the thyroarytenoid muscle. This treatment significantly decreased the standard deviation of the fundamental frequency of the speech sample, indicating a reduction in the variability of pitch amongst patients. A total of 96% of patients' subjective diary reports showed an improvement with a median of 7 days to peak effect and a 5 week duration of peak effect.

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