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Paraneoplastic cerebellar degeneration and limbic encephalitis in a patient with adenocarcinoma of the colon.
  1. T Tsukamoto,
  2. R Mochizuki,
  3. H Mochizuki,
  4. M Noguchi,
  5. H Kayama,
  6. M Hiwatashi,
  7. T Yamamoto
  1. Department of Neurology, Fukushima Medical College, Japan.


    The rare association of two neurological paraneoplastic syndromes, paraneoplastic cerebellar degeneration and limbic encephalitis occurred in a 55 year old woman with a microscopic adenocarcinoma in a colonic polyp. Complete removal of the tumour by polypectomy brought about a favourable recovery from limbic encephalitis but the cerebellar ataxia remained. High titres of antineuronal nuclear antibody resembling anti-Hu were demonstrated in serum by immunohistochemistry using rat brain as a substrate. The antibody identified a protein band of 41 kDa on a Western immunoblot.

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