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A clinico-pathological study of adult histiocytosis X involving the brain.
  1. K Hasegawa,
  2. T Mitomi,
  3. H Kowa,
  4. T Motoori,
  5. S Yagisita
  1. Department of Neurology, Kitasato University School of Medicine, Kanagawa, Japan.


    Adult histiocytosis X involving the CNS caused progressive spastic paraparesis. The diagnosis was made by immunoreactive anti-S100 protein antibody staining and from the presence of Birbeck granules in biopsy specimens of skin lesions. Neuropathological examination showed massive proliferation and infiltration of S-100 containing histiocyte-like cells and reactive astrocytes throughout the CNS.

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