Article Text

Download PDFPDF

Folate deficiency in cerebrospinal fluid associated with a defect in folate binding protein in the central nervous system.
  1. R A Wevers,
  2. S I Hansen,
  3. J L van Hellenberg Hubar,
  4. J Holm,
  5. M Høier-Madsen,
  6. P J Jongen
  1. Institute of Neurology, University Hospital of Nijmegen, The Netherlands.


    An adult male patient of Dutch ancestry has a slowly progressive neurological disease characterised by a cerebellar syndrome, distal spinal muscular atrophy, pyramidal tract dysfunction, and perceptive hearing loss. A severe folate deficiency state was found in CSF in combination with a normal serum and red cell folate state. Two unknown abnormal metabolites were present in CSF. The concentration of immunoreactive folate binding protein in CSF was unusually low, whereas the concentration of the protein measured with radioligand (3H-folate) binding was unusually high. The transfer of folate over the choroid plexus seems to be disturbed, potentially reflecting a defect in the choroid plexus folate binder.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.