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Amnesic syndrome after theophylline associated seizures: iatrogenic brain injury.
  1. J I O'Riordan,
  2. J Hutchinson,
  3. M X FitzGerald,
  4. M Hutchinson
  1. Department of Neurology, St Vincent's Hospital, Dublin, Ireland.


    Two patients developed a disabling amnesic syndrome after seizures associated with oral theophylline treatment. Such seizures are more likely in the elderly, in the presence of pre-existing neurological disease, and when theophylline is given with certain antibiotics and cimetidine. The mechanism of neuronal injury may be by the excessive release of endogenous excitotoxic glutamate.

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