Article Text

Download PDFPDF
Motor neuron disease (amyotrophic lateral sclerosis) arising from longstanding primary lateral sclerosis.
  1. R P Bruyn,
  2. J H Koelman,
  3. D Troost,
  4. J M de Jong
  1. Department of Neurology, Oudenryn Hospital, Utrecht, The Netherlands.


    Three men were initially diagnosed as having primary lateral sclerosis (PLS), but eventually developed amyotrophic lateral sclerosis (ALS) after 7.5, 9, and at least 27 years. Non-familial ALS and PLS might be different manifestations of a single disease or constitute completely distinct entities. The clinical diagnosis of PLS predicts a median survival that is four to five times longer than in ALS.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.