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Sequence of the superoxide dismutase 1 (SOD 1) gene in familial Parkinson's disease.
  1. O Bandmann,
  2. M B Davis,
  3. C D Marsden,
  4. A E Harding
  1. University Department of Clinical Neurology, (Neurogenetics Section), Institute of Neurology, London, UK.


    Mutations in the superoxide dismutase 1 (SOD1) gene have been detected in affected members of some families with familial amyotrophic lateral sclerosis. To evaluate the possibility of a shared genetic defect in amyotrophic lateral sclerosis and Parkinson's disease, the SOD1 gene was sequenced in index patients with familial Parkinson's disease from 23 families. No changes were detected.

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