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Cytomegalovirus infections and anti-GM2 antibodies in Guillain-Barré syndrome.
  1. B C Jacobs,
  2. P A van Doorn,
  3. J H Groeneveld,
  4. A P Tio-Gillen,
  5. F G van der Meché
  1. Department of Neurology, University Hospital Dijkzigt and Erasmus University, Rotterdam, The Netherlands.


    To investigate whether antecedent cytomegalovirus (CMV) infections in patients with Guillain-Barré syndrome are associated with the presence of specific antiganglioside antibodies, acute phase serum samples from 130 patients with Guillain-Barré syndrome and 200 controls were tested. Anti-GM2 IgM antibodies were found more often in patients with Guillain-Barré syndrome with CMV infection (22%) than in patients without the infection (2%) (P = 0.003). CMV infections may elicit anti-GM2 antibodies in susceptible patients, which may contribute to the pathogenesis of Guillain-Barré syndrome associated with CMV.

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