Interferon-γ induced increases in intracellular calcium in T lymphocytes from patients with multiple sclerosis precede clinical exacerbations and detection of active lesions on MRI

G Martino; M Filippi; V Martinelli; E Brambilla; C Gobbi; G Comi; L M E Grimaldi

doi:10.1136/jnnp.63.3.339

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Interferon-γ induced increases in intracellular calcium in T lymphocytes from patients with multiple sclerosis precede clinical exacerbations and detection of active lesions on MRI

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Online download statistics by month: March 1999 to May 2023

	Abstract	Full	Pdf
Mar 1999	3	7	3
Apr 1999	0	1	3
May 1999	1	3	4
Jun 1999	1	1	2
Jul 1999	1	0	0
Sep 1999	0	1	0
Nov 1999	3	6	2
Dec 1999	1	1	0
Jan 2000	0	2	2
Feb 2000	1	1	0
Mar 2000	0	2	1
Apr 2000	1	3	0
May 2000	0	3	1
Jun 2000	0	0	1
Aug 2000	0	3	1
Sep 2000	0	2	4
Oct 2000	6	2	2
Nov 2000	3	6	3
Dec 2000	0	1	1
Jan 2001	0	1	0
Feb 2001	0	0	1
Mar 2001	0	2	1
Apr 2001	0	1	0
Jun 2001	0	3	0
Jul 2001	0	2	1
Aug 2001	0	2	1
Sep 2001	0	1	0
Oct 2001	0	1	1
Jan 2002	0	4	0
Feb 2002	0	5	0
Mar 2002	0	3	1
Apr 2002	0	1	0
May 2002	0	3	0
Jun 2002	4	4	0
Jul 2002	0	2	3
Aug 2002	1	2	1
Sep 2002	0	3	0
Oct 2002	0	6	8
Dec 2002	0	5	2
Jan 2003	1	1	1
Feb 2003	0	4	4
Mar 2003	0	1	0
Apr 2003	0	2	1
Jun 2003	2	1	2
Jul 2003	0	3	5
Aug 2003	1	1	0
Sep 2003	0	2	2
Oct 2003	1	5	0
Nov 2003	3	6	3
Dec 2003	0	1	0
Jan 2004	0	1	0
Feb 2004	0	2	0
Mar 2004	1	0	0
Apr 2004	0	2	0
May 2004	0	1	0
Jun 2004	3	6	0
Jul 2004	11	17	1
Aug 2004	12	18	0
Sep 2004	3	14	2
Oct 2004	4	29	4
Nov 2004	6	28	2
Dec 2004	5	21	0
Jan 2005	4	21	1
Feb 2005	10	30	1
Mar 2005	8	20	0
Apr 2005	3	11	5
May 2005	0	15	1
Jun 2005	1	20	2
Jul 2005	0	1	0
Aug 2005	2	12	5
Sep 2005	2	5	1
Oct 2005	2	8	1
Nov 2005	3	7	2
Dec 2005	2	4	0
Jan 2006	2	7	0
Feb 2006	2	5	1
Mar 2006	6	7	1
Apr 2006	1	2	0
May 2006	1	3	2
Jun 2006	1	2	1
Jul 2006	0	3	0
Aug 2006	1	1	2
Sep 2006	1	8	0
Oct 2006	2	4	1
Nov 2006	3	1	1
Dec 2006	1	3	3
Jan 2007	3	3	5
Feb 2007	2	4	1
Mar 2007	1	5	2
Apr 2007	4	3	4
May 2007	0	1	0
Jun 2007	1	5	1
Jul 2007	0	0	1
Aug 2007	2	2	1
Sep 2007	4	0	1
Oct 2007	5	2	0
Nov 2007	3	3	1
Dec 2007	0	1	0
Jan 2008	2	2	2
Feb 2008	5	4	3
Mar 2008	2	3	0
Apr 2008	3	1	2
May 2008	3	0	0
Jun 2008	7	2	1
Jul 2008	2	0	0
Aug 2008	6	1	0
Sep 2008	3	1	0
Oct 2008	2	1	0
Nov 2008	2	2	0
Dec 2008	3	2	0
Mar 2009	1	1	1
Apr 2009	0	0	1
May 2009	2	0	1
Jun 2009	1	0	0
Jul 2009	2	0	0
Aug 2009	0	1	1
Sep 2009	2	0	1
Oct 2009	2	0	1
Nov 2009	5	1	3
Dec 2009	8	0	2
Jan 2010	0	1	1
Feb 2010	2	1	2
Mar 2010	4	0	2
Apr 2010	2	0	0
May 2010	4	1	1
Jun 2010	5	0	5
Jul 2010	6	1	0
Aug 2010	3	1	4
Sep 2010	1	2	0
Oct 2010	3	1	0
Nov 2010	12	1	0
Dec 2010	3	0	1
Jan 2011	1	4	0
Feb 2011	5	0	0
Mar 2011	4	0	0
Apr 2011	4	1	0
May 2011	1	0	1
Jun 2011	4	1	0
Jul 2011	4	0	0
Aug 2011	5	0	0
Sep 2011	4	1	1
Oct 2011	4	0	1
Nov 2011	4	2	0
Dec 2011	4	3	1
Jan 2012	12	3	2
Feb 2012	5	2	3
Mar 2012	7	3	5
Apr 2012	6	5	4
May 2012	9	3	4
Jun 2012	8	6	3
Jul 2012	6	4	5
Aug 2012	6	5	8
Sep 2012	9	3	7
Oct 2012	30	4	7
Nov 2012	24	7	7
Dec 2012	3	4	6
Jan 2013	9	7	4
Feb 2013	10	6	9
Mar 2013	2	4	1
Apr 2013	6	2	7
May 2013	6	6	3
Jun 2013	5	1	1
Jul 2013	2	1	2
Aug 2013	5	1	2
Sep 2013	4	1	0
Oct 2013	2	16	3
Nov 2013	3	5	1
Dec 2013	1	2	1
Jan 2014	4	4	6
Feb 2014	5	3	3
Mar 2014	10	2	5
Apr 2014	8	8	3
May 2014	4	6	0
Jun 2014	0	7	2
Jul 2014	5	14	0
Aug 2014	3	5	0
Sep 2014	1	2	1
Oct 2014	0	3	0
Nov 2014	2	2	0
Dec 2014	3	5	2
Jan 2015	3	2	0
Feb 2015	0	1	4
Mar 2015	11	5	1
Apr 2015	11	6	3
May 2015	5	1	3
Jun 2015	1	0	0
Jul 2015	1	1	1
Aug 2015	3	2	4
Sep 2015	5	4	0
Oct 2015	4	0	10
Nov 2015	4	1	0
Dec 2015	1	2	0
Jan 2016	1	0	2
Feb 2016	1	0	2
Mar 2016	4	0	1
Apr 2016	4	2	3
May 2016	2	3	0
Jun 2016	1	1	1
Jul 2016	0	0	5
Aug 2016	2	0	0
Sep 2016	4	1	4
Oct 2016	3	1	1
Nov 2016	0	3	2
Dec 2016	1	0	1
Jan 2017	3	0	3
Feb 2017	2	2	0
Mar 2017	1	2	0
Apr 2017	0	7	0
May 2017	0	4	0
Jun 2017	2	12	5
Jul 2017	6	5	0
Aug 2017	6	6	0
Sep 2017	6	6	2
Oct 2017	6	6	1
Nov 2017	2	2	0
Dec 2017	5	5	0
Jan 2018	5	5	0
Feb 2018	14	9	1
Mar 2018	11	3	0
Apr 2018	6	6	1
May 2018	7	7	0
Jun 2018	17	15	0
Jul 2018	10	6	3
Aug 2018	8	8	3
Sep 2018	3	3	0
Oct 2018	6	4	0
Nov 2018	4	4	1
Dec 2018	5	5	0
Jan 2019	2	2	2
Mar 2019	2	2	2
Apr 2019	3	3	3
May 2019	5	5	4
Jun 2019	2	2	15
Jul 2019	7	7	9
Aug 2019	2	2	3
Sep 2019	5	5	2
Oct 2019	4	4	1
Nov 2019	9	9	1
Dec 2019	4	4	3
Jan 2020	4	4	2
Feb 2020	6	4	1
Mar 2020	0	0	4
Apr 2020	5	5	1
May 2020	9	9	2
Jun 2020	5	5	4
Jul 2020	12	8	2
Aug 2020	2	2	2
Sep 2020	8	8	0
Oct 2020	14	14	4
Nov 2020	13	13	0
Dec 2020	11	11	2
Jan 2021	9	8	1
Feb 2021	10	10	3
Mar 2021	9	9	3
Apr 2021	4	4	2
May 2021	2	2	0
Jun 2021	6	6	1
Jul 2021	5	5	3
Aug 2021	3	3	1
Sep 2021	4	4	4
Oct 2021	2	2	11
Nov 2021	7	7	13
Dec 2021	11	11	3
Jan 2022	9	9	6
Feb 2022	6	6	0
Mar 2022	8	8	2
Apr 2022	9	9	3
May 2022	23	23	6
Jun 2022	27	27	3
Jul 2022	12	11	2
Aug 2022	22	22	2
Sep 2022	20	19	5
Oct 2022	21	19	4
Nov 2022	7	7	3
Dec 2022	2	2	0
Jan 2023	8	8	3
Feb 2023	19	19	1
Mar 2023	4	4	5
Apr 2023	3	3	5
Total	1152	1259	513

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