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Expression of tenascin in astrocytic tumours: too much ado about nothing?
  1. G DONATO,
  2. A LAVANO,
  3. G VOLPENTESTA,
  4. D CHIRCHIGLIA,
  5. C D SIGNORELLI
  1. Department of Neurosurgery of the University of Reggio Calabria, School of Medicine (Catanzaro), Italy
  2. Department of Pathology, General Hospital “A Pugliese” (Catanzaro), Italy
  1. Dr G Donato, Department of Neurosurgery, Policlinico “Mater Domini”, Via T Campanella, 88100 Catanzaro, Italy.
  1. L TUCCI
  1. Department of Neurosurgery of the University of Reggio Calabria, School of Medicine (Catanzaro), Italy
  2. Department of Pathology, General Hospital “A Pugliese” (Catanzaro), Italy
  1. Dr G Donato, Department of Neurosurgery, Policlinico “Mater Domini”, Via T Campanella, 88100 Catanzaro, Italy.

https://doi.org/10.1136/jnnp.63.3.413

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    Glioblastoma. Immunohistochemical staining for tenascin is in the basement membrane zone of tumour vessels and also in the extracellular matrix (originally ×125).

    The stroma of astrocytic tumours has been investigated in the past years by various authors. Among the proteins of the extracellular matrix tenascin is considered a very important molecule because of presumed links with the malignancy of the tumours and with the angiogenesis1 2 and also a possible target for therapy. To verify these opinions we have performed an immunohistochemical analysis of 10 astrocytic tumours of the cerebral hemispheres. The series of patients comprised six men and four women, ranging in age from 43 to 72 years; seven underwent …

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