Catechol-O-methyltransferase inhibition with tolcapone reduces the “wearing off” phenomenon and levodopa requirements in fluctuating parkinsonian patients

H Baas; A G Beiske; J Ghika; M Jackson; W H Oertel; W Poewe; G Ransmayr

doi:10.1136/jnnp.63.4.421

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Paper

Catechol-O-methyltransferase inhibition with tolcapone reduces the “wearing off” phenomenon and levodopa requirements in fluctuating parkinsonian patients

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Online download statistics by month: March 1999 to March 2024

	Abstract	Full	Pdf
Mar 1999	3	5	5
Apr 1999	0	6	2
May 1999	2	7	5
Jun 1999	0	2	3
Jul 1999	0	1	0
Aug 1999	2	8	0
Sep 1999	1	0	0
Oct 1999	1	2	1
Nov 1999	4	5	4
Dec 1999	2	2	0
Jan 2000	2	4	6
Feb 2000	3	5	3
Mar 2000	2	3	3
Apr 2000	1	4	4
May 2000	1	0	2
Jul 2000	0	0	1
Aug 2000	2	2	1
Sep 2000	2	4	1
Oct 2000	8	15	1
Nov 2000	5	5	1
Dec 2000	1	0	2
Jan 2001	1	1	0
Feb 2001	3	0	4
Mar 2001	0	11	0
Apr 2001	0	9	1
May 2001	0	1	0
Jun 2001	1	5	0
Jul 2001	0	1	0
Aug 2001	2	3	1
Oct 2001	0	8	0
Nov 2001	2	12	1
Dec 2001	0	1	0
Jan 2002	7	7	0
Feb 2002	2	3	0
Mar 2002	0	4	0
Apr 2002	0	6	0
May 2002	5	2	0
Jun 2002	1	5	0
Jul 2002	1	6	1
Aug 2002	0	1	3
Sep 2002	1	7	2
Oct 2002	2	5	1
Nov 2002	0	1	6
Dec 2002	0	9	4
Jan 2003	4	6	6
Mar 2003	4	3	3
Apr 2003	0	14	8
May 2003	3	5	6
Jun 2003	2	8	2
Jul 2003	2	1	0
Aug 2003	5	4	2
Sep 2003	0	10	4
Oct 2003	7	14	3
Nov 2003	6	11	9
Dec 2003	0	8	8
Jan 2004	1	5	4
Feb 2004	4	3	2
Mar 2004	2	6	1
Apr 2004	0	6	4
May 2004	1	5	4
Jun 2004	5	8	5
Jul 2004	11	21	4
Aug 2004	15	22	4
Sep 2004	6	26	6
Oct 2004	9	58	7
Nov 2004	12	64	17
Dec 2004	7	23	6
Jan 2005	13	38	3
Feb 2005	13	38	2
Mar 2005	13	34	9
Apr 2005	7	27	8
May 2005	10	18	4
Jun 2005	11	14	4
Jul 2005	2	9	7
Aug 2005	4	16	14
Sep 2005	8	9	4
Oct 2005	11	10	3
Nov 2005	9	18	2
Dec 2005	9	12	2
Jan 2006	6	20	9
Feb 2006	4	15	3
Mar 2006	6	44	14
Apr 2006	7	17	10
May 2006	5	9	4
Jun 2006	4	9	9
Jul 2006	2	9	7
Aug 2006	5	10	6
Sep 2006	8	15	10
Oct 2006	13	16	7
Nov 2006	15	10	7
Dec 2006	6	12	6
Jan 2007	7	3	7
Feb 2007	5	12	14
Mar 2007	10	7	5
Apr 2007	12	4	2
May 2007	2	6	10
Jun 2007	5	3	7
Jul 2007	9	14	8
Aug 2007	11	4	7
Sep 2007	6	7	4
Oct 2007	11	1	1
Nov 2007	7	2	5
Dec 2007	4	1	2
Jan 2008	9	2	4
Feb 2008	15	2	5
Mar 2008	18	4	7
Apr 2008	16	1	4
May 2008	12	3	4
Jun 2008	7	0	5
Jul 2008	8	2	3
Aug 2008	9	1	0
Sep 2008	16	2	2
Oct 2008	13	1	2
Nov 2008	12	4	6
Dec 2008	6	3	3
Jan 2009	6	3	3
Feb 2009	4	2	1
Mar 2009	6	2	2
Apr 2009	13	1	6
May 2009	9	2	3
Jun 2009	6	2	2
Jul 2009	8	1	2
Aug 2009	3	0	1
Sep 2009	8	0	0
Oct 2009	6	2	1
Nov 2009	6	3	3
Dec 2009	10	0	1
Jan 2010	7	0	1
Feb 2010	16	1	3
Mar 2010	18	2	2
Apr 2010	16	0	0
May 2010	15	3	2
Jun 2010	7	0	4
Jul 2010	8	2	0
Aug 2010	3	2	1
Sep 2010	9	1	2
Oct 2010	6	2	4
Nov 2010	18	4	2
Dec 2010	14	3	2
Jan 2011	13	2	1
Feb 2011	10	9	4
Mar 2011	17	0	1
Apr 2011	11	1	3
May 2011	4	1	0
Jun 2011	7	1	2
Jul 2011	6	3	0
Aug 2011	13	1	1
Sep 2011	15	3	3
Oct 2011	13	7	4
Nov 2011	11	6	1
Dec 2011	13	6	8
Jan 2012	9	23	3
Feb 2012	11	19	3
Mar 2012	20	10	5
Apr 2012	17	11	10
May 2012	9	11	8
Jun 2012	13	17	2
Jul 2012	12	14	7
Aug 2012	16	19	9
Sep 2012	8	9	7
Oct 2012	15	9	7
Nov 2012	18	24	20
Dec 2012	18	8	9
Jan 2013	26	18	6
Feb 2013	20	9	3
Mar 2013	13	14	4
Apr 2013	16	17	10
May 2013	8	13	5
Jun 2013	5	20	3
Jul 2013	3	6	1
Aug 2013	1	3	4
Sep 2013	5	7	3
Oct 2013	8	18	3
Nov 2013	9	5	3
Dec 2013	12	15	8
Jan 2014	2	4	0
Feb 2014	4	13	7
Mar 2014	15	18	11
Apr 2014	8	14	3
May 2014	6	9	3
Jun 2014	5	9	6
Jul 2014	31	12	7
Aug 2014	56	6	1
Sep 2014	52	8	6
Oct 2014	44	10	3
Nov 2014	116	5	3
Dec 2014	32	9	2
Jan 2015	30	6	2
Feb 2015	36	8	3
Mar 2015	29	12	2
Apr 2015	54	10	2
May 2015	41	10	2
Jun 2015	22	3	2
Jul 2015	17	5	2
Aug 2015	23	3	2
Sep 2015	32	6	3
Oct 2015	32	5	6
Nov 2015	23	3	0
Dec 2015	33	1	5
Jan 2016	33	3	3
Feb 2016	30	8	5
Mar 2016	27	3	7
Apr 2016	8	4	1
May 2016	8	3	4
Jun 2016	6	5	5
Jul 2016	4	4	7
Aug 2016	10	8	3
Sep 2016	35	4	6
Oct 2016	21	2	1
Nov 2016	42	3	3
Dec 2016	22	3	5
Jan 2017	49	12	4
Feb 2017	6	8	1
Mar 2017	4	25	2
Apr 2017	5	37	3
May 2017	9	20	0
Jun 2017	2	15	1
Jul 2017	22	19	3
Aug 2017	22	17	2
Sep 2017	32	24	3
Oct 2017	40	32	11
Nov 2017	35	23	0
Dec 2017	14	8	5
Jan 2018	33	19	5
Feb 2018	42	30	8
Mar 2018	39	27	5
Apr 2018	39	31	5
May 2018	92	90	2
Jun 2018	31	23	2
Jul 2018	29	19	3
Aug 2018	53	51	3
Sep 2018	46	36	9
Oct 2018	67	63	3
Nov 2018	70	66	9
Dec 2018	66	62	4
Jan 2019	67	63	5
Feb 2019	53	52	7
Mar 2019	27	28	8
Apr 2019	16	10	10
May 2019	10	10	3
Jun 2019	18	16	5
Jul 2019	44	34	10
Aug 2019	8	8	6
Sep 2019	9	5	3
Oct 2019	9	10	0
Nov 2019	12	11	3
Dec 2019	21	15	8
Jan 2020	20	14	5
Feb 2020	13	13	8
Mar 2020	29	19	43
Apr 2020	8	8	5
May 2020	28	20	5
Jun 2020	10	7	5
Jul 2020	10	6	1
Aug 2020	8	2	7
Sep 2020	14	12	5
Oct 2020	9	9	5
Nov 2020	19	13	1
Dec 2020	16	8	11
Jan 2021	23	18	3
Feb 2021	9	9	8
Mar 2021	20	16	7
Apr 2021	21	17	16
May 2021	19	19	3
Jun 2021	14	14	4
Jul 2021	15	15	6
Aug 2021	14	14	4
Sep 2021	13	13	5
Oct 2021	18	16	14
Nov 2021	7	7	10
Dec 2021	13	12	1
Jan 2022	13	16	8
Feb 2022	33	31	12
Mar 2022	37	32	10
Apr 2022	39	36	10
May 2022	29	27	9
Jun 2022	40	40	13
Jul 2022	27	25	2
Aug 2022	26	21	2
Sep 2022	49	39	11
Oct 2022	54	47	12
Nov 2022	34	32	6
Dec 2022	22	18	4
Jan 2023	32	28	9
Feb 2023	43	43	1
Mar 2023	34	22	8
Apr 2023	28	23	9
May 2023	26	22	7
Jun 2023	19	18	3
Jul 2023	16	15	6
Aug 2023	25	21	4
Sep 2023	19	20	3
Oct 2023	26	25	6
Nov 2023	32	24	7
Dec 2023	71	6	2
Jan 2024	49	3	2
Feb 2024	39	1	2
Mar 2024	104	0	0
Total	4710	3628	1318

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