Chromosome 14 familial Alzheimer’s disease: the clinical and neuropathological characteristics of a family with a leucine→serine (L250S) substitution at codon 250 of the presenilin 1 gene

Richard J Harvey; David Ellison; John Hardy; Mike Hutton; Penelope K Roques; John Collinge; Nick C Fox; Martin N Rossor

doi:10.1136/jnnp.64.1.44

Article metrics

Paper

Chromosome 14 familial Alzheimer’s disease: the clinical and neuropathological characteristics of a family with a leucine→serine (L250S) substitution at codon 250 of the presenilin 1 gene

Online download statistics by month:

Online download statistics by month: March 1999 to August 2024

	Abstract	Full	Pdf
Mar 1999	3	6	3
Apr 1999	1	7	9
May 1999	1	4	7
Jun 1999	2	6	4
Jul 1999	1	1	2
Aug 1999	2	1	1
Sep 1999	1	2	0
Oct 1999	1	2	3
Nov 1999	8	10	0
Dec 1999	1	3	1
Jan 2000	1	5	2
Feb 2000	1	1	1
Mar 2000	1	7	3
Apr 2000	1	6	7
May 2000	1	1	1
Jun 2000	0	2	1
Aug 2000	0	5	6
Sep 2000	0	2	2
Oct 2000	3	7	4
Nov 2000	4	10	5
Dec 2000	0	5	10
Feb 2001	1	2	2
Mar 2001	1	5	3
Apr 2001	1	3	3
May 2001	2	2	1
Jun 2001	0	5	4
Jul 2001	0	4	3
Aug 2001	0	6	1
Sep 2001	0	1	0
Oct 2001	0	1	0
Nov 2001	0	5	0
Dec 2001	0	4	1
Jan 2002	2	2	4
Feb 2002	1	10	4
Mar 2002	1	3	5
Apr 2002	1	1	1
May 2002	0	5	13
Jun 2002	0	3	0
Jul 2002	1	2	2
Aug 2002	0	4	3
Sep 2002	0	2	0
Oct 2002	0	3	2
Nov 2002	1	8	5
Dec 2002	2	12	6
Jan 2003	1	3	6
Feb 2003	0	6	1
Mar 2003	4	9	5
Apr 2003	0	1	0
May 2003	0	3	2
Jun 2003	1	3	2
Jul 2003	0	3	1
Aug 2003	1	7	6
Sep 2003	0	2	2
Oct 2003	0	2	2
Nov 2003	8	10	4
Dec 2003	3	10	0
Jan 2004	1	4	3
Feb 2004	1	3	3
Mar 2004	7	3	1
Apr 2004	0	1	2
Jun 2004	3	14	8
Jul 2004	23	22	1
Aug 2004	17	21	0
Sep 2004	7	24	9
Oct 2004	13	76	6
Nov 2004	24	122	9
Dec 2004	21	108	7
Jan 2005	31	114	5
Feb 2005	41	211	17
Mar 2005	35	150	8
Apr 2005	27	176	8
May 2005	18	88	5
Jun 2005	9	22	1
Jul 2005	1	33	2
Aug 2005	21	35	7
Sep 2005	14	30	5
Oct 2005	8	48	6
Nov 2005	25	56	8
Dec 2005	7	38	1
Jan 2006	10	58	6
Feb 2006	8	77	10
Mar 2006	6	148	11
Apr 2006	4	126	11
May 2006	9	57	11
Jun 2006	3	21	7
Jul 2006	3	10	2
Aug 2006	4	23	6
Sep 2006	7	32	9
Oct 2006	10	55	4
Nov 2006	24	89	11
Dec 2006	8	54	8
Jan 2007	15	84	14
Feb 2007	6	99	7
Mar 2007	17	146	16
Apr 2007	50	19	3
May 2007	74	5	1
Jun 2007	17	10	6
Jul 2007	23	11	9
Aug 2007	19	4	4
Sep 2007	13	3	0
Oct 2007	14	11	2
Nov 2007	29	6	4
Dec 2007	30	0	1
Jan 2008	54	3	2
Feb 2008	39	5	0
Mar 2008	53	9	2
Apr 2008	59	11	4
May 2008	15	2	0
Jun 2008	11	1	2
Jul 2008	5	2	2
Aug 2008	10	1	3
Sep 2008	10	5	3
Oct 2008	19	0	0
Nov 2008	23	3	2
Dec 2008	21	5	2
Jan 2009	24	1	2
Feb 2009	21	4	5
Mar 2009	19	1	2
Apr 2009	26	2	6
May 2009	14	2	1
Jun 2009	5	2	2
Jul 2009	3	4	3
Aug 2009	3	2	0
Sep 2009	5	2	4
Oct 2009	15	7	1
Nov 2009	25	1	0
Dec 2009	27	1	0
Jan 2010	19	1	1
Feb 2010	20	3	1
Mar 2010	17	0	0
Apr 2010	14	1	4
May 2010	14	3	1
Jun 2010	8	0	2
Jul 2010	8	1	0
Aug 2010	27	1	2
Sep 2010	36	7	2
Oct 2010	41	15	1
Nov 2010	46	9	1
Dec 2010	36	7	2
Jan 2011	32	7	2
Feb 2011	32	5	0
Mar 2011	38	5	1
Apr 2011	38	4	1
May 2011	17	6	0
Jun 2011	15	2	0
Jul 2011	23	4	2
Aug 2011	10	4	1
Sep 2011	18	6	0
Oct 2011	35	1	1
Nov 2011	29	25	1
Dec 2011	7	73	9
Jan 2012	8	103	5
Feb 2012	8	78	4
Mar 2012	6	85	2
Apr 2012	5	82	11
May 2012	3	114	14
Jun 2012	4	37	7
Jul 2012	9	42	12
Aug 2012	9	25	2
Sep 2012	5	45	12
Oct 2012	8	37	8
Nov 2012	15	65	20
Dec 2012	8	28	13
Jan 2013	14	45	9
Feb 2013	8	38	16
Mar 2013	10	42	5
Apr 2013	12	40	11
May 2013	11	33	8
Jun 2013	3	16	5
Jul 2013	8	16	6
Aug 2013	2	10	4
Sep 2013	6	13	7
Oct 2013	5	16	1
Nov 2013	5	29	20
Dec 2013	2	29	11
Jan 2014	3	14	8
Feb 2014	2	143	9
Mar 2014	11	33	16
Apr 2014	7	58	45
May 2014	15	85	62
Jun 2014	3	22	44
Jul 2014	5	27	32
Aug 2014	8	7	4
Sep 2014	7	13	4
Oct 2014	5	4	14
Nov 2014	2	3	1
Dec 2014	10	9	7
Jan 2015	4	16	6
Feb 2015	4	7	10
Mar 2015	2	11	4
Apr 2015	6	8	5
May 2015	8	9	1
Jun 2015	14	11	1
Jul 2015	8	4	8
Aug 2015	0	9	3
Sep 2015	6	6	10
Oct 2015	5	5	15
Nov 2015	6	13	19
Dec 2015	5	18	9
Jan 2016	9	12	11
Feb 2016	1	1	10
Mar 2016	15	7	8
Apr 2016	8	8	12
May 2016	7	7	12
Jun 2016	2	10	8
Jul 2016	8	11	3
Aug 2016	1	9	4
Sep 2016	10	9	9
Oct 2016	8	7	6
Nov 2016	9	128	5
Dec 2016	3	22	4
Jan 2017	8	37	4
Feb 2017	1	87	5
Mar 2017	2	34	5
Apr 2017	1	49	0
May 2017	4	43	2
Jun 2017	2	15	1
Jul 2017	18	15	0
Aug 2017	21	21	0
Sep 2017	35	31	0
Oct 2017	30	26	3
Nov 2017	47	41	2
Dec 2017	38	34	0
Jan 2018	32	24	3
Feb 2018	45	41	7
Mar 2018	48	38	4
Apr 2018	46	38	2
May 2018	41	32	3
Jun 2018	24	18	3
Jul 2018	14	12	3
Aug 2018	14	10	3
Sep 2018	30	28	4
Oct 2018	33	31	4
Nov 2018	28	28	6
Dec 2018	31	29	3
Jan 2019	22	22	6
Feb 2019	25	24	4
Mar 2019	45	43	9
Apr 2019	25	21	10
May 2019	27	23	6
Jun 2019	22	22	4
Jul 2019	27	20	8
Aug 2019	19	19	7
Sep 2019	19	20	10
Oct 2019	39	37	4
Nov 2019	46	44	7
Dec 2019	41	38	7
Jan 2020	35	35	7
Feb 2020	27	27	11
Mar 2020	43	43	12
Apr 2020	21	19	6
May 2020	23	19	11
Jun 2020	14	14	8
Jul 2020	19	18	8
Aug 2020	10	8	6
Sep 2020	28	16	3
Oct 2020	38	38	10
Nov 2020	41	39	14
Dec 2020	36	34	11
Jan 2021	42	37	14
Feb 2021	40	40	10
Mar 2021	45	45	6
Apr 2021	37	35	29
May 2021	21	21	10
Jun 2021	16	16	5
Jul 2021	18	18	6
Aug 2021	8	8	8
Sep 2021	13	13	9
Oct 2021	13	13	21
Nov 2021	15	14	21
Dec 2021	40	40	10
Jan 2022	19	19	3
Feb 2022	23	23	2
Mar 2022	56	53	13
Apr 2022	36	36	6
May 2022	57	58	20
Jun 2022	35	34	5
Jul 2022	33	34	4
Aug 2022	39	39	4
Sep 2022	42	38	13
Oct 2022	49	49	7
Nov 2022	33	33	4
Dec 2022	34	33	13
Jan 2023	25	21	6
Feb 2023	52	52	0
Mar 2023	27	26	3
Apr 2023	25	25	10
May 2023	35	33	11
Jun 2023	26	24	8
Jul 2023	33	32	7
Aug 2023	12	12	7
Sep 2023	30	28	5
Oct 2023	183	178	6
Nov 2023	337	337	6
Dec 2023	256	24	4
Jan 2024	43	4	4
Feb 2024	47	1	1
Mar 2024	149	6	0
Apr 2024	76	2	0
May 2024	38	2	1
Jun 2024	50	0	2
Jul 2024	50	1	0
Aug 2024	36	1	0
Total	5888	7855	1756

Log in using your username and password

Main menu

Log in using your username and password

You are here

Online download statistics by month:

Online download statistics by month: March 1999 to August 2024

Read the full text or download the PDF:

Log in using your username and password