Exploratory treatment trials in multiple sclerosis using MRI: sample size calculations for relapsing-remitting and secondary progressive subgroups using placebo controlled parallel groups

N Tubridy; H J Ader; F Barkhof; A J Thompson; D H Miller

doi:10.1136/jnnp.64.1.50

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Exploratory treatment trials in multiple sclerosis using MRI: sample size calculations for relapsing-remitting and secondary progressive subgroups using placebo controlled parallel groups

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Online download statistics by month: March 1999 to April 2023

	Abstract	Full	Pdf
Mar 1999	7	10	6
Apr 1999	1	6	6
May 1999	2	7	8
Jun 1999	2	4	2
Jul 1999	2	4	1
Aug 1999	2	2	3
Sep 1999	1	0	1
Oct 1999	1	1	0
Nov 1999	5	9	2
Dec 1999	1	3	0
Jan 2000	0	4	3
Feb 2000	1	2	0
Mar 2000	0	11	6
Apr 2000	1	3	0
May 2000	0	1	1
Jun 2000	1	3	0
Jul 2000	0	4	2
Aug 2000	1	1	0
Sep 2000	3	1	4
Oct 2000	2	9	3
Nov 2000	4	10	2
Dec 2000	2	6	2
Jan 2001	0	2	0
Feb 2001	0	5	3
Mar 2001	2	9	1
Apr 2001	2	9	2
May 2001	1	6	1
Jun 2001	1	5	0
Jul 2001	0	3	4
Aug 2001	0	5	3
Sep 2001	2	2	1
Oct 2001	1	2	0
Nov 2001	1	8	0
Dec 2001	0	1	0
Jan 2002	1	9	0
Feb 2002	1	4	0
Mar 2002	2	12	5
Apr 2002	4	5	4
May 2002	2	9	4
Jun 2002	1	0	2
Jul 2002	2	5	4
Aug 2002	1	18	5
Sep 2002	0	2	1
Oct 2002	1	3	2
Nov 2002	3	8	9
Dec 2002	3	6	3
Jan 2003	1	4	4
Feb 2003	4	5	5
Mar 2003	0	16	11
Apr 2003	5	9	8
May 2003	1	5	8
Jun 2003	2	8	11
Jul 2003	1	3	5
Aug 2003	1	5	6
Sep 2003	0	5	4
Oct 2003	0	2	1
Nov 2003	3	11	13
Dec 2003	0	3	2
Jan 2004	1	3	7
Feb 2004	3	6	10
Mar 2004	0	9	13
Apr 2004	0	6	7
May 2004	2	2	3
Jun 2004	2	7	2
Jul 2004	16	21	7
Aug 2004	16	29	4
Sep 2004	8	14	8
Oct 2004	12	21	6
Nov 2004	8	36	8
Dec 2004	11	17	4
Jan 2005	18	43	13
Feb 2005	9	23	8
Mar 2005	38	33	7
Apr 2005	17	39	18
May 2005	11	17	11
Jun 2005	8	39	9
Jul 2005	10	26	4
Aug 2005	20	34	18
Sep 2005	6	35	14
Oct 2005	18	16	12
Nov 2005	6	28	12
Dec 2005	6	12	4
Jan 2006	17	17	12
Feb 2006	8	18	11
Mar 2006	7	19	7
Apr 2006	6	17	7
May 2006	19	30	8
Jun 2006	14	24	5
Jul 2006	5	25	8
Aug 2006	0	13	4
Sep 2006	7	18	2
Oct 2006	7	24	9
Nov 2006	7	23	4
Dec 2006	6	13	3
Jan 2007	5	22	4
Feb 2007	11	20	9
Mar 2007	11	21	14
Apr 2007	3	2	2
May 2007	18	6	2
Jun 2007	14	6	5
Jul 2007	12	13	5
Aug 2007	16	2	4
Sep 2007	14	7	5
Oct 2007	10	1	2
Nov 2007	12	5	4
Dec 2007	4	2	4
Jan 2008	10	4	5
Feb 2008	8	4	4
Mar 2008	8	5	8
Apr 2008	11	4	3
May 2008	17	0	2
Jun 2008	22	4	2
Jul 2008	6	1	2
Aug 2008	8	1	2
Sep 2008	8	3	1
Oct 2008	3	0	1
Nov 2008	6	1	1
Dec 2008	5	2	2
Jan 2009	3	1	1
Feb 2009	5	2	2
Mar 2009	4	4	1
Apr 2009	3	5	3
May 2009	3	2	3
Jun 2009	1	2	7
Jul 2009	7	3	9
Aug 2009	3	1	1
Sep 2009	10	2	1
Oct 2009	7	6	3
Nov 2009	9	2	2
Dec 2009	7	2	3
Jan 2010	7	1	3
Feb 2010	4	0	4
Mar 2010	5	2	3
Apr 2010	5	0	1
May 2010	2	2	1
Jun 2010	3	1	4
Jul 2010	4	1	4
Aug 2010	2	1	2
Sep 2010	3	1	0
Oct 2010	7	1	1
Nov 2010	16	2	1
Dec 2010	6	1	3
Jan 2011	20	3	10
Feb 2011	8	1	2
Mar 2011	2	1	2
Apr 2011	5	0	0
May 2011	6	1	1
Jun 2011	5	2	0
Jul 2011	6	0	0
Aug 2011	11	1	0
Sep 2011	2	1	1
Oct 2011	10	2	1
Nov 2011	9	1	1
Dec 2011	5	4	6
Jan 2012	9	1	2
Feb 2012	17	2	0
Mar 2012	25	3	0
Apr 2012	27	5	7
May 2012	28	14	7
Jun 2012	16	5	7
Jul 2012	17	8	4
Aug 2012	9	7	5
Sep 2012	10	7	7
Oct 2012	6	4	8
Nov 2012	22	11	6
Dec 2012	8	7	7
Jan 2013	24	7	11
Feb 2013	19	5	5
Mar 2013	13	8	4
Apr 2013	14	13	9
May 2013	11	4	5
Jun 2013	6	1	2
Jul 2013	4	1	3
Aug 2013	6	3	5
Sep 2013	5	4	0
Oct 2013	4	5	1
Nov 2013	6	5	1
Dec 2013	2	2	4
Jan 2014	3	1	5
Feb 2014	9	7	6
Mar 2014	8	4	1
Apr 2014	14	10	3
May 2014	11	19	4
Jun 2014	1	15	0
Jul 2014	10	4	6
Aug 2014	9	6	6
Sep 2014	9	2	0
Oct 2014	6	2	2
Nov 2014	2	2	0
Dec 2014	9	2	1
Jan 2015	6	3	0
Feb 2015	4	1	5
Mar 2015	2	3	1
Apr 2015	7	4	1
May 2015	6	4	1
Jun 2015	4	2	2
Jul 2015	4	0	3
Aug 2015	0	11	0
Sep 2015	4	3	0
Oct 2015	8	4	6
Nov 2015	4	31	2
Dec 2015	10	25	1
Jan 2016	5	8	2
Feb 2016	3	9	1
Mar 2016	3	1	2
Apr 2016	3	1	0
May 2016	1	27	0
Jun 2016	7	4	10
Jul 2016	2	1	0
Aug 2016	7	3	1
Sep 2016	7	2	3
Oct 2016	25	10	2
Nov 2016	25	20	3
Dec 2016	9	4	0
Jan 2017	7	0	0
Feb 2017	3	2	3
Mar 2017	0	4	1
Apr 2017	3	7	0
May 2017	4	9	0
Jun 2017	6	10	3
Jul 2017	12	10	2
Aug 2017	10	10	1
Sep 2017	11	11	1
Oct 2017	7	5	0
Nov 2017	18	8	4
Dec 2017	12	6	3
Jan 2018	12	10	1
Feb 2018	21	13	5
Mar 2018	8	4	0
Apr 2018	13	13	1
May 2018	18	17	0
Jun 2018	18	10	0
Jul 2018	8	6	1
Aug 2018	17	7	3
Sep 2018	7	5	0
Oct 2018	8	8	3
Nov 2018	10	10	0
Dec 2018	8	8	0
Jan 2019	6	2	1
Feb 2019	4	4	2
Mar 2019	7	5	4
Apr 2019	6	5	6
May 2019	12	8	5
Jun 2019	1	1	4
Jul 2019	3	3	1
Aug 2019	4	4	3
Sep 2019	5	4	2
Oct 2019	7	5	2
Nov 2019	8	6	1
Dec 2019	6	6	3
Jan 2020	4	4	3
Feb 2020	5	5	4
Mar 2020	4	3	6
Apr 2020	2	2	2
May 2020	8	8	2
Jun 2020	14	11	8
Jul 2020	27	22	19
Aug 2020	9	8	4
Sep 2020	13	12	3
Oct 2020	38	34	7
Nov 2020	15	13	5
Dec 2020	14	10	2
Jan 2021	13	13	8
Feb 2021	3	3	5
Mar 2021	6	6	1
Apr 2021	7	7	1
May 2021	5	5	1
Jun 2021	4	4	1
Jul 2021	7	7	4
Aug 2021	10	7	7
Sep 2021	12	10	8
Oct 2021	14	10	15
Nov 2021	14	8	19
Dec 2021	16	12	7
Jan 2022	30	25	5
Feb 2022	21	17	1
Mar 2022	22	14	10
Apr 2022	12	8	5
May 2022	27	27	7
Jun 2022	26	23	3
Jul 2022	17	15	1
Aug 2022	30	24	4
Sep 2022	25	23	9
Oct 2022	25	21	4
Nov 2022	12	11	4
Dec 2022	11	9	2
Jan 2023	11	11	4
Feb 2023	22	22	2
Mar 2023	9	10	1
Apr 2023	9	7	5
Total	2332	2394	1118

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