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Accumulation of oncofetal fibronectin in the vessels of anaplastic meningiomas
  1. ANTONIO PAU,
  2. LUCA BRUZZONE,
  3. ALESSANDRA DORCARATTO,
  4. GIUSEPPE VIALE
  1. Division of Neurosurgery, University of Genoa Medical Scool, Genoa, Italy
  2. Departement of Internal Medicine, Nuclear Medicine Service, University of
  3. Genoa Medical School, Genoa, Italy
  4. Laboratory of Cell Biology, Istituto per la Ricerca sul Cancro, Genoa, Italy
  1. Dr Antonio Pau, Clinica Neurochirurgica dell’Universita degli Studi Ospedale S, Martino Largo Rosanna Benzi, 10 16132 Genova, Italia. Telephone 039 10 3537610; fax 039 10 352104.
  1. GIULIANO MARIANI
  1. Division of Neurosurgery, University of Genoa Medical Scool, Genoa, Italy
  2. Departement of Internal Medicine, Nuclear Medicine Service, University of
  3. Genoa Medical School, Genoa, Italy
  4. Laboratory of Cell Biology, Istituto per la Ricerca sul Cancro, Genoa, Italy
  1. Dr Antonio Pau, Clinica Neurochirurgica dell’Universita degli Studi Ospedale S, Martino Largo Rosanna Benzi, 10 16132 Genova, Italia. Telephone 039 10 3537610; fax 039 10 352104.
  1. PATRIZIA CASTELLANI,
  2. ANNALISA SIRI,
  3. LUCIANO ZARDI
  1. Division of Neurosurgery, University of Genoa Medical Scool, Genoa, Italy
  2. Departement of Internal Medicine, Nuclear Medicine Service, University of
  3. Genoa Medical School, Genoa, Italy
  4. Laboratory of Cell Biology, Istituto per la Ricerca sul Cancro, Genoa, Italy
  1. Dr Antonio Pau, Clinica Neurochirurgica dell’Universita degli Studi Ospedale S, Martino Largo Rosanna Benzi, 10 16132 Genova, Italia. Telephone 039 10 3537610; fax 039 10 352104.

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Fibronectins (FNs), polymorphic high molecular mass glycoproteins of the extracellular matrix, are known to play a major part in various processes including wound healing and oncogenic transformation. A B+FN isoform, characterised by peculiar sequence and splicing patterns,1 has been found to be widely expressed in fetal and neoplastic tissues, in sharp contrast with the highly restricted distribution in normal adult tissues, including human brain. This isoform, named “oncofetal FN”, has recently been recognised as a marker of angiogenesis, with its expression being paramount in the hyperplastic endothelia of human glioblastomas.2 On the other hand, several reports have stressed the role of angiogenesis in sustaining growth and invasive potential of malignant tumours. In view of the possible clinical use of radiolabelled monoclonal antibodies (MoAb) able to selectively bind components of the tumorous vasculature as potential angiosuppressive agents for postoperative treatment of cerebral malignancies, angiogenic factors and markers in these tumours are worthy of further study. In this regard, primary anaplastic meningiomas, although relatively rare, represent a challenge, because an aggressive treatment including adjuvant combined modality therapy may affect the poor outcome and warrant palliation of the disease.3 The purpose of the present report was to analyse the distribution of the oncofetal FN in the vessels of a series of human malignant meningiomas and to ascertain whether the occurrence of this isoform may represent …

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