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Peripheral neuropathies among patients with HIV infection
  1. MARIA BARBARA ALLIEGRO,
  2. ANDREA PETRUCCI
  1. Istituto Superiore di Sanità, Laboratory of Epidemiology and Biostatistics, Centro Operativo AIDS, Rome, Italy
  2. CISN e TeB, Roma, Italy
  3. Istituto Superiore di Sanità, Laboratory of Epidemiology and Biostatistics, Centro Operativo AIDS, Rome, Italy
  4. University of Bari, Italy
  5. Centro Antivenereo, Milan, Italy
  6. University of Turin, Italy
  7. University of Genova, Italy
  8. For the Italian Seroconversion Study Group
  1. Dr Maria Barbara Alliegro, Centro Operativo AIDS, Istituto Superiore di Sanità, Viale Regina Elena, 29900161 Roma, Italy. Telephone 0039 6 4990 2337; fax 0039 6 49387210; email: mallibar{at}net.iss.it
  1. CARLA ARPINO
  1. Istituto Superiore di Sanità, Laboratory of Epidemiology and Biostatistics, Centro Operativo AIDS, Rome, Italy
  2. CISN e TeB, Roma, Italy
  3. Istituto Superiore di Sanità, Laboratory of Epidemiology and Biostatistics, Centro Operativo AIDS, Rome, Italy
  4. University of Bari, Italy
  5. Centro Antivenereo, Milan, Italy
  6. University of Turin, Italy
  7. University of Genova, Italy
  8. For the Italian Seroconversion Study Group
  1. Dr Maria Barbara Alliegro, Centro Operativo AIDS, Istituto Superiore di Sanità, Viale Regina Elena, 29900161 Roma, Italy. Telephone 0039 6 4990 2337; fax 0039 6 49387210; email: mallibar{at}net.iss.it
  1. MARIA DORRUCCI,
  2. PATRIZIO PEZZOTTI,
  3. GIOVANNI REZZA
  1. Istituto Superiore di Sanità, Laboratory of Epidemiology and Biostatistics, Centro Operativo AIDS, Rome, Italy
  2. CISN e TeB, Roma, Italy
  3. Istituto Superiore di Sanità, Laboratory of Epidemiology and Biostatistics, Centro Operativo AIDS, Rome, Italy
  4. University of Bari, Italy
  5. Centro Antivenereo, Milan, Italy
  6. University of Turin, Italy
  7. University of Genova, Italy
  8. For the Italian Seroconversion Study Group
  1. Dr Maria Barbara Alliegro, Centro Operativo AIDS, Istituto Superiore di Sanità, Viale Regina Elena, 29900161 Roma, Italy. Telephone 0039 6 4990 2337; fax 0039 6 49387210; email: mallibar{at}net.iss.it
  1. GIOVANNI BUCCOLIERO
  1. Istituto Superiore di Sanità, Laboratory of Epidemiology and Biostatistics, Centro Operativo AIDS, Rome, Italy
  2. CISN e TeB, Roma, Italy
  3. Istituto Superiore di Sanità, Laboratory of Epidemiology and Biostatistics, Centro Operativo AIDS, Rome, Italy
  4. University of Bari, Italy
  5. Centro Antivenereo, Milan, Italy
  6. University of Turin, Italy
  7. University of Genova, Italy
  8. For the Italian Seroconversion Study Group
  1. Dr Maria Barbara Alliegro, Centro Operativo AIDS, Istituto Superiore di Sanità, Viale Regina Elena, 29900161 Roma, Italy. Telephone 0039 6 4990 2337; fax 0039 6 49387210; email: mallibar{at}net.iss.it
  1. GLORIA TARANTINI
  1. Istituto Superiore di Sanità, Laboratory of Epidemiology and Biostatistics, Centro Operativo AIDS, Rome, Italy
  2. CISN e TeB, Roma, Italy
  3. Istituto Superiore di Sanità, Laboratory of Epidemiology and Biostatistics, Centro Operativo AIDS, Rome, Italy
  4. University of Bari, Italy
  5. Centro Antivenereo, Milan, Italy
  6. University of Turin, Italy
  7. University of Genova, Italy
  8. For the Italian Seroconversion Study Group
  1. Dr Maria Barbara Alliegro, Centro Operativo AIDS, Istituto Superiore di Sanità, Viale Regina Elena, 29900161 Roma, Italy. Telephone 0039 6 4990 2337; fax 0039 6 49387210; email: mallibar{at}net.iss.it
  1. ALESSANDRO SINICCO
  1. Istituto Superiore di Sanità, Laboratory of Epidemiology and Biostatistics, Centro Operativo AIDS, Rome, Italy
  2. CISN e TeB, Roma, Italy
  3. Istituto Superiore di Sanità, Laboratory of Epidemiology and Biostatistics, Centro Operativo AIDS, Rome, Italy
  4. University of Bari, Italy
  5. Centro Antivenereo, Milan, Italy
  6. University of Turin, Italy
  7. University of Genova, Italy
  8. For the Italian Seroconversion Study Group
  1. Dr Maria Barbara Alliegro, Centro Operativo AIDS, Istituto Superiore di Sanità, Viale Regina Elena, 29900161 Roma, Italy. Telephone 0039 6 4990 2337; fax 0039 6 49387210; email: mallibar{at}net.iss.it
  1. ANDREA CANESSA
  1. Istituto Superiore di Sanità, Laboratory of Epidemiology and Biostatistics, Centro Operativo AIDS, Rome, Italy
  2. CISN e TeB, Roma, Italy
  3. Istituto Superiore di Sanità, Laboratory of Epidemiology and Biostatistics, Centro Operativo AIDS, Rome, Italy
  4. University of Bari, Italy
  5. Centro Antivenereo, Milan, Italy
  6. University of Turin, Italy
  7. University of Genova, Italy
  8. For the Italian Seroconversion Study Group
  1. Dr Maria Barbara Alliegro, Centro Operativo AIDS, Istituto Superiore di Sanità, Viale Regina Elena, 29900161 Roma, Italy. Telephone 0039 6 4990 2337; fax 0039 6 49387210; email: mallibar{at}net.iss.it

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Peripheral neuropathies often affect patients with HIV disease,1 and various peripheral neuropathies have been described at different stages of HIV infection, from seroconversion to AIDS. Acute inflammatory demyelinating polyneuropathies have been found in association with primary HIV infection; chronic inflammatory demyelinating polyneuropathies, isolated mononeuritis, and multiplex mononeuritis have more commonly been described in those in advanced stages of HIV disease, and distal symmetric polyneuropathy has been found to be the most common neuropathy among persons with AIDS. In most cases, the aetiopathogenesis of these neuropathies is still unclear, although various factors have been implicated (infectious, metabolic, immunological, inflammatory, nutritional, and toxic).2 To date, relatively few studies have estimated the incidence of peripheral neuropathies among HIV infected patients belonging to different population groups. Data derived from the Multicenter AIDS Cohort Study showed annual rates slightly higher than 1.5/100 person-years for sensory neuropathy.3 Another study found a roughly 1% annual incidence of neuropathies in symptomatic patients without AIDS.4 To estimate the incidence of peripheral neuropathies during the different stages of HIV disease, we analysed data …

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