Article Text
Letters to the editor
Concurrent herpes simplex virus encephalitis and Creutzfeldt-Jakob disease
Statistics from Altmetric.com
Hsich et al recently described the 14–3–3 protein marker for Creutzfeldt-Jakob disease in which they noted a high number of positive assays (11 of 12) for the 14–3–3 protein in the CSF of patients with herpes simplex virus (HSV) encephalitis.1 We report the case of a previously healthy 71 year old woman admitted to hospital with subacute changes in mental status who developed a rapidly progressive dementia characterised by personality change, insomnia, ataxia, and myoclonus. Brain MRI was unremarkable. Serial EEG was markedly abnormal due to the presence of diffuse slowing and continuous bilateral sharp waves with regular or irregular periodicity. Analysis of CSF at LCNSS, NIH showed strong immunoreactivity for …