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Acute autonomic and sensory neuropathy (AASN) is characterised by severe autonomic dysfunction, sensory deficit, and relatively well or fully preserved motor nerve function.1-4 The disease sometimes has a chronic course.2 4 Detailed information is limited because there have been so few reports of the postmortem examination of AASN.2-4 This case provides histopathological evidence for autonomic and sensory ganglionopathy in AASN.
A 30 year old Japanese man had abdominal pain and a rise in body temperature to 40°C on 1 January 1990. On 23 January, he felt prickling and paraesthesia in all his limbs. On 14 February he could no longer walk due to severe prickling of the entire body. On 2 March, he became bedridden because of orthostatic hypotension. He experienced mild weakness in the all limbs, dysarthria, and dysphagia. On 13 March, he was transferred to our hospital. Physical examination on admission showed anhidrosis, urinary retention, hyposalivation, and paralytic ileus. There was no history of intoxication by …