Article Text

Download PDFPDF
Subacute autonomic and sensory ganglionopathy: a postmortem case
  1. MARIE SATAKE
  1. Department of Neurology, Faculty of Medicine, Kyushu University,Japan
  2. Department of Neuropathology, Neurological Institute, Faculty of Medicine, Kyushu University, Japan
  3. Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Japan
  4. Department of Psychosomatic Medicine Iizuka Hospital, Japan
  5. Department of Neurology, Iizuka Hospital, Japan
  6. Department of Neurology, Faculty of Medicine, Kyushu University,Japan
  7. Department of Neuropathology, Neurological Institute, Kyushu University, Japan
  1. Dr Marie Satake, Department of Neurology, Neurological Institute, Faculty of Medicine, Kyushu University 60, Higashi-ku, Fukuoka 812–82, Japan. Fax 0081 92 642 5352.
  1. YASUSHI NAKAGAWA
  1. Department of Neurology, Faculty of Medicine, Kyushu University,Japan
  2. Department of Neuropathology, Neurological Institute, Faculty of Medicine, Kyushu University, Japan
  3. Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Japan
  4. Department of Psychosomatic Medicine Iizuka Hospital, Japan
  5. Department of Neurology, Iizuka Hospital, Japan
  6. Department of Neurology, Faculty of Medicine, Kyushu University,Japan
  7. Department of Neuropathology, Neurological Institute, Kyushu University, Japan
  1. Dr Marie Satake, Department of Neurology, Neurological Institute, Faculty of Medicine, Kyushu University 60, Higashi-ku, Fukuoka 812–82, Japan. Fax 0081 92 642 5352.
  1. SAYURI YAMASHITA
  1. Department of Neurology, Faculty of Medicine, Kyushu University,Japan
  2. Department of Neuropathology, Neurological Institute, Faculty of Medicine, Kyushu University, Japan
  3. Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Japan
  4. Department of Psychosomatic Medicine Iizuka Hospital, Japan
  5. Department of Neurology, Iizuka Hospital, Japan
  6. Department of Neurology, Faculty of Medicine, Kyushu University,Japan
  7. Department of Neuropathology, Neurological Institute, Kyushu University, Japan
  1. Dr Marie Satake, Department of Neurology, Neurological Institute, Faculty of Medicine, Kyushu University 60, Higashi-ku, Fukuoka 812–82, Japan. Fax 0081 92 642 5352.
  1. ETSUKO HASHIGUCHI
  1. Department of Neurology, Faculty of Medicine, Kyushu University,Japan
  2. Department of Neuropathology, Neurological Institute, Faculty of Medicine, Kyushu University, Japan
  3. Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Japan
  4. Department of Psychosomatic Medicine Iizuka Hospital, Japan
  5. Department of Neurology, Iizuka Hospital, Japan
  6. Department of Neurology, Faculty of Medicine, Kyushu University,Japan
  7. Department of Neuropathology, Neurological Institute, Kyushu University, Japan
  1. Dr Marie Satake, Department of Neurology, Neurological Institute, Faculty of Medicine, Kyushu University 60, Higashi-ku, Fukuoka 812–82, Japan. Fax 0081 92 642 5352.
  1. NAOKI FUJII
  1. Department of Neurology, Faculty of Medicine, Kyushu University,Japan
  2. Department of Neuropathology, Neurological Institute, Faculty of Medicine, Kyushu University, Japan
  3. Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Japan
  4. Department of Psychosomatic Medicine Iizuka Hospital, Japan
  5. Department of Neurology, Iizuka Hospital, Japan
  6. Department of Neurology, Faculty of Medicine, Kyushu University,Japan
  7. Department of Neuropathology, Neurological Institute, Kyushu University, Japan
  1. Dr Marie Satake, Department of Neurology, Neurological Institute, Faculty of Medicine, Kyushu University 60, Higashi-ku, Fukuoka 812–82, Japan. Fax 0081 92 642 5352.
  1. TAKEO YOSHIMURA
  1. Department of Neurology, Faculty of Medicine, Kyushu University,Japan
  2. Department of Neuropathology, Neurological Institute, Faculty of Medicine, Kyushu University, Japan
  3. Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Japan
  4. Department of Psychosomatic Medicine Iizuka Hospital, Japan
  5. Department of Neurology, Iizuka Hospital, Japan
  6. Department of Neurology, Faculty of Medicine, Kyushu University,Japan
  7. Department of Neuropathology, Neurological Institute, Kyushu University, Japan
  1. Dr Marie Satake, Department of Neurology, Neurological Institute, Faculty of Medicine, Kyushu University 60, Higashi-ku, Fukuoka 812–82, Japan. Fax 0081 92 642 5352.
  1. TORU IWAKI
  1. Department of Neurology, Faculty of Medicine, Kyushu University,Japan
  2. Department of Neuropathology, Neurological Institute, Faculty of Medicine, Kyushu University, Japan
  3. Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Japan
  4. Department of Psychosomatic Medicine Iizuka Hospital, Japan
  5. Department of Neurology, Iizuka Hospital, Japan
  6. Department of Neurology, Faculty of Medicine, Kyushu University,Japan
  7. Department of Neuropathology, Neurological Institute, Kyushu University, Japan
  1. Dr Marie Satake, Department of Neurology, Neurological Institute, Faculty of Medicine, Kyushu University 60, Higashi-ku, Fukuoka 812–82, Japan. Fax 0081 92 642 5352.

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Acute autonomic and sensory neuropathy (AASN) is characterised by severe autonomic dysfunction, sensory deficit, and relatively well or fully preserved motor nerve function.1-4 The disease sometimes has a chronic course.2 4 Detailed information is limited because there have been so few reports of the postmortem examination of AASN.2-4 This case provides histopathological evidence for autonomic and sensory ganglionopathy in AASN.

(A) Section from the lumbar dorsal root ganglia: There are only a few normal lumbar dorsal root ganglia neurons. (B) Section from the sympathetic ganglion: normal nerve cell bodies have disappeared and been replaced by clusters of cells (“nodules of Nageotte” (arrows)). Originally×100.

A 30 year old Japanese man had abdominal pain and a rise in body temperature to 40°C on 1 January 1990. On 23 January, he felt prickling and paraesthesia in all his limbs. On 14 February he could no longer walk due to severe prickling of the entire body. On 2 March, he became bedridden because of orthostatic hypotension. He experienced mild weakness in the all limbs, dysarthria, and dysphagia. On 13 March, he was transferred to our hospital. Physical examination on admission showed anhidrosis, urinary retention, hyposalivation, and paralytic ileus. There was no history of intoxication by …

View Full Text

Linked Articles