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Factors associated with psychotic symptoms in Alzheimer’s disease
  1. Nobutsugu Hironoa,
  2. Etsuro Moria,
  3. Minoru Yasudab,
  4. Yoshitaka Ikejiria,
  5. Toru Imamuraa,
  6. Tatsuo Shimomuraa,
  7. Manabu Ikedaa,
  8. Mamoru Hashimotoa,
  9. Hikari Yamashitaa
  1. aDivision of Clinical Neurosciences, bDivision of Basic Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
  1. Dr Nobutsugu Hirono, Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, 520 Saisho-ko, Himeji, 670 Japan. Telephone 0081 792 95 5511; fax 0081 792 95 8199; emailhirono{at}


OBJECTIVES Many clinical and biological factors have been reported to be associated with the presence of psychosis in patients with Alzheimer’s disease, although the associations were variable. The aim of this study was to clarify factors associated with the presence of psychosis in patients with Alzheimer’s disease.

METHODS Psychiatric functioning was studied in 228 patients with Alzheimer’s disease based on the results of the behavioural pathology in Alzheimer’s disease rating scale or the neuropsychiatric inventory. The effects of sex, education level, age, duration of illness, cognitive function, and apolipoprotein E genotype were investigated for dichotomous psychotic status with a multiple logistic regression analysis.

RESULTS Of the 228 patients with Alzheimer’s disease, 118 (51.8%) showed evidence of delusions or hallucinations. Of these, 94 had delusions only, three had hallucinations only, and 21 had both. Older age, female sex, longer duration of illness, and more severe cognitive impairment were the factors independently associated with the presence of psychosis. The presence of psychosis was not significantly related to either educational level or apolipoprotein E genotype.

CONCLUSIONS Age, sex, and severity of illness were independent factors associated with the presence of psychosis in patients with Alzheimer’s disease. The reason why some patients with Alzheimer’s disease develop psychosis remains unclear. There may be distinctive subtypes of Alzheimer’s disease or the presence of individual factors which affect the development of psychosis.

  • Alzheimer’s disease
  • psychotic symptoms
  • apolipoprotein E

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Psychotic symptoms are common in patients with Alzheimer’s disease and have a major impact on their quality of life and social affiliations. In a review of 21 studies, Wragg and Jeste1reported that the prevalence of delusion ranged from 10% to 73% (median 33.5%) and that of hallucination ranged from 21% to 49% (median 28%) in patients with Alzheimer’s disease at some time in the course of their illness. Drevets and Rubin2 reported that the prevalence of delusions and hallucinations in patients with Alzheimer’s disease ranged from 13% to 75% and from 3% to 50%, respectively. Psychotic symptoms have been shown to be a major cause of anxiety and concern for caregivers3 4 and a frequent cause of admission to an institution.5 6 Because appropriate management of behavioural symptoms may lessen the burden of care givers and may postpone admission to an institution, evaluation and management of psychotic symptoms are of considerable importance in practice.

The underlying mechanism for psychosis in Alzheimer’s disease is not well understood. Although psychosis has been reported to be associated with many clinical and biological factors, such as age,7-11 sex,12-14 duration of illness,15 education level,13 cognitive impairment,13 16–21 and apolipoprotein E (ApoE) genotypes,22 the associations were variable. These inconsistencies are likely explained by one or more methodological factors: (1) the lack of statistical power with small sample sizes; (2) differing diagnostic criteria of the disease and definition of the psychotic symptoms; and (3) the lack of consideration of interactions among factors. In the present study, we examined a large series of patients with Alzheimer’s disease for the presence of psychosis by using standardised assessment instruments of psychopathology for patients with dementia, and multivariate statistics to concurrently analyse the patients’ characteristics that are possibly related to psychosis.


All procedures of this study strictly followed the clinical study guidelines of the ethics committee of Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan (1993), and were approved by the internal review board. After a complete description of all procedures of this study, written informed consent was obtained from patients or their relatives.

The subjects of this study were 228 of a consecutive series of 312 Japanese patients with sporadic Alzheimer’s disease who were given a short term admission to our hospital for examination between July 1993 and September 1996. All patients were examined by both neurologists and psychiatrists and were given routine laboratory tests and standard neuropsychological examinations. In addition, EEG, brain MRI, MR angiography of the neck and head, and cerebral perfusion/metabolism studies by PET or single photon emission computed tomography (SPECT) were done. All results were incorporated in the diagnosis. The inclusion criteria were those of both the Diagnostic and Statistical Manual of Mental Disorders, either Third Edition-Revised (DSM-III-R)23 or Fourth Edition (DSM-IV)23a for Dementia of the Alzheimer’s Type and the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer’s Disease and Related Disorders Association24 for probable Alzheimer’s disease. Eighty four patients who were admitted during the study period were not studied because of the exclusion criteria, consisting of complications of other neurological diseases or illness resulting from physical disease, evidence of parkinsonism or focal brain lesions on MRI, the presence of severe hearing or vision impairments, a history of mental illness or substance misuse before the onset of dementia, the absence of reliable informants, such as living with family or care givers, or the inability to obtain informed consent.

The included patients consisted of 173 women and 55 men; the mean (SD) age at examination was 72.7 (8.2) years and the mean educational attainment was 8.9 (2.2) years. The functional severity was very mild in 30 patients, mild in 119 patients, moderate in 63 patients, and severe in 16 patients as determined by the clinical dementia rating scale.25 The mean age at symptom onset and duration of symptoms determined with informant based interviews were 67.1 (7.5) years and 37.3 (28.8) months respectively. The mean value of the mini mental state examination (MMSE)26 was 18.5 (5.1). Twenty three patients could not complete the Wechsler adult intelligence scale-revised.27 The mean values of the remaining 205 patients were 77.0 (10.4) for verbal-IQ, 75.1 (13.7) for performance-IQ, and 74.3 (11.9) for full-IQ. The mean number of words recalled in the 10 word list recall subtest of the Alzheimer’s disease assessment scale-cognitive part28 was 3.3 (1.6).

According to DSM-IV,23a delusion was defined as a firmly sustained, false belief based on incorrect inference about external reality not attributable to the patient’s cultural or subcultural experience, and hallucination was defined as sensory perception that has the compelling sense of reality of a true perception but that occurs without external stimulation of the relevant sensory organ. With the behavioural pathology in Alzheimer’s disease rating scale12 or the neuropsychiatric inventory,29a single rater assessed each patient’s psychiatric condition during an interview with the care giver. In this study, delusions and hallucinations were rated on a present or absent basis. The patient was rated as psychotic when he or she had either delusions or hallucinations.

The age at onset and the duration of the disease were ascertained through an interview with the primary care giver. Age at onset was defined as the age of the first appearance of symptoms of sufficient severity to interfere with social or occupational functioning and the duration was defined as the time in months between the onset and the admission.30

The detailed method for ApoE genotyping is described elsewhere.31 In brief, genomic DNA was extracted from whole blood samples by the phenol/chloroform method and was amplified by the polymerase chain reaction (PCR) as described by Wenham et al.32 The PCR products were digested with 10 units Hha I for five hours at 37°C. The DNA fragments were electrophoresed for five hours at 60 mA through a 15% non-denaturing polyacrylamide gel. The gel was stained with ethidium bromide and photographed under ultraviolet light. The genotypes were determined by the size of DNA fragments. The patients with one or more ApoE ε4 alleles were rated as ε4 positive and the others were rated as ε4 negative.

We used the χ2 test for binary variables, and the two tailed t test for continuous variables for unadjusted comparisons of patients with and without psychosis. For correlational analyses, we used Pearson correlation coefficients. To examine the specific characteristics that predict psychosis, a multiple logistic analysis was used, with psychosis as a dependent variable and the patients’ characteristics (sex, education level, duration of illness, MMSE, ApoE genotype, and either age at onset or age at examination) as independent variables. Because age at examination and age at onset were strongly correlated, which causes multicolinearity, each variable was examined in separate models. All statistical analyses were carried out with SAS Release 6.10 software (SAS Institute Inc).


The ApoE genotyping was ε2/3 in eight patients, ε2/4 in three patients, ε3/3 in 78 patients, ε3/4 in 115 patients, and ε4/4 in 24 patients. Thus, the ApoE ε4 gene was positive in 142 patients and negative in 86 patients. As expected, the age at examination was highly correlated with the age at onset (r=0.96, p < 0.0001). The educational attainment was inversely correlated with both age at examination (r=−0.31, p<0.0001) and age at onset (r=−0.32, p<0.0001). Both mean age at examination and age at onset were significantly greater in women than in men (73.3 (SD 7.8) v 70.7 (9.2), p=0.046; 70.4 (8.30) v67.5 (9.37), p=0.034)). The mean educational attainment was significantly less in women than in men (8.6 (SD 2.1) v9.6 (2.3), p=0.0048)). Although age, education level, and the MMSE score did not differ significantly between the ApoE ε4 positive patients and the ε4 negative patients, the mean duration of illness was significantly greater in the ε4 positive patients than in the ε4 negative patients (39.0 (SD 30.9) v 30.9 (23.6) months, p=0.038).

Of the 228 patients, 118 (51.8%) were rated as psychotic. Of these 118 patients, 21 had both delusions and hallucinations, 94 had delusions only, and three had hallucinations only. Thus 115 (50.4%) of the patients had delusions. Of these, 91 patients had persecutory delusions (88 patients had delusions that “people are stealing things”, 10 patients had delusions of “being conspired against or harassed”, and three patients had a delusion of abandonment), 58 patients had misidentification delusions (42 patients had delusions that “someone was in the house”, 11 patients had delusions that “the house was not their own”, six patients had delusions that “television figures are actually present in the home”, and six patients had other types of misidentification), three patients had delusional jealousy, one patient had a delusion of poverty, one patient had grandiose delusions, and one patient had eromanic delusions. Some patients had two or more kinds of delusions. Twenty four (10.5%) of the patients had hallucinations. Of these, 16 had visual hallucinations, 14 had auditory hallucinations, and one had olfactory hallucinations. Seven patients had two types of hallucinations.

Table 1 compares the characteristics of patients with and without psychosis. Those with the psychosis were significantly older, had an older age of onset, had a longer duration of illness, and had less education than those without psychosis. The proportion of women was significantly higher in the psychotic group than in the non-psychotic group. There were no significant associations between psychosis and ApoE genotype. The mean MMSE score was significantly lower in patients with psychosis than in the those without psychosis.

Table 1

Comparison of characteristics between patients with and without psychosis

Table 2 shows the results of the first model of multiple logistic regression in which age at onset was included, and table 3 shows that of the second model including age at examination. Both models indicated that the effects of age, sex, and MMSE were significantly associated with the presence of psychosis. In the first model but not in the second, duration of illness was a significant risk factor for psychosis. The level of education was not a significant predictor of psychosis in either model. The ApoE genotype also had no significant association with psychosis.

Table 2

Results of multiple logistic regression analysis with age at onset included

Table 3

Results of multiple logistic regression analysis with age at examination included


The present study provides further evidence that psychotic symptoms are a common manifestation of Alzheimer’s disease. The prevalences of delusions (51.8%) and hallucinations (10.5%) were well within the ranges reported in the literature.1 2 The finding that persecutory delusions (especially the belief that people are stealing or hiding objects) were the most common psychotic manifestations was also compatible with the findings of previous studies.9 12 14 16 17 20 33 Because patients who had parkinsonism were excluded from this study, the chance of erroneous inclusion of those with dementia with Lewy bodies,34 in whom neuropsychiatric symptoms are common, was small. The major findings of our study were that sex, age, and severity of cognitive impairment were each significantly and independently associated with psychosis, and that the level of education and the frequency of the ApoE ε4 allele were not significant predictors of the presence of psychosis.

Previous studies have disagreed on the contribution of cognitive impairment in psychotic symptoms. Some studies failed to show a difference in cognitive impairment between the patients with and without psychosis,7 10 11 14 15 35-37 whereas others showed that psychotic symptoms were associated with poor13 17-19 21 or preserved16 20cognitive function. These controversies are likely due to the inclusion of patients with different severities of dementia. Psychotic symptoms were considered to be uncommon in both the very mild33 and very severe18 20 stages of Alzheimer’s disease. A longitudinal study2 disclosed that delusions in patients with Alzheimer’s disease were relatively more frequent during the moderate stage. The small proportion of advanced patients included in our study contributed to the positive correlation between psychosis and cognitive impairments. In any case, as the difference in MMSE between groups was small, the effect of cognitive impairment in psychosis would be modest. Nevertheless, it is conceivable that a dysfunction of specific cognitive domains is associated with psychosis.

In this study, duration of illness was shown to be an independent predictor of psychosis in the logistic regression model in which age at onset was the variable, although it was not significant in the model when age at examination was the variable. It is plausible that the effect of duration of illness was masked by the effect of the age at examination, because the age at examination is a function of age at onset and duration of illness. Our results supported the conclusion of the study of Migliorelli et al,15 who reported that patients with Alzheimer’s disease with delusions had a significantly longer duration of illness than those without delusions, whereas most previous studies failed to show a significant association between duration of illness and psychosis.8 10 13 18 20 21 35-38 An association between development of psychotic symptoms and a rapid mental deterioration has been found in several longitudinal studies.2 9 33 39 40 This does not disagree with our finding that psychotic patients with Alzheimer’s disease had a significantly longer duration of illness, because long duration does not necessarily imply slow progression of the disease. Our findings that a decreased MMSE and a longer duration of illness were separate factors associated with the presence of psychosis would suggest that deterioration of both cognitive and non-cognitive functions promotes psychosis independently.

Older age was shown to be a significant risk factor for psychosis in both logistic regression models in this study. The issue of the effect of age on psychosis in Alzheimer’s disease is highly controversial. Several investigators7-11 showed that older patients were more likely to have psychotic symptoms, whereas Gilly et al 8 reported that early onset was significantly associated with psychosis when cognitive functions were severely impaired. Devanand et al 13 maintained that age at examination was associated with paranoid delusions and inversely correlated with hallucinations. Moreover, many studies failed to show a significant relation between age and psychosis.12 15 17-21 35-38 41 42 However, evidence that supports the relation between older age and development of psychosis is available in studies focusing on localisation of pathological changes in relation to age and psychosis. Senile plaques both in the temporal neocortex and in the hippocampus were more frequent in younger patients with Alzheimer’s disease than in elder patients,43 44 whereas psychosis in Alzheimer’s disease is reportedly inversely related to the preservation in those areas.45

We also found a significant association between female sex and development of psychosis. Although female sex has been implicated as a risk factor for Alzheimer’s disease, few studies have considered whether sex specifically predisposes patients to the development of psychotic symptoms in Alzheimer’s disease. Devanand et al 13 reported that women’s scores of delusion on the Columbia University scale for psychopathology were significantly higher than those of men. Reisberg et al 12found that women tended to exhibit behavioural symptoms more often. On the other hand, Burns et al 14 reported a higher prevalence in men of delusions of theft. Other studies failed to show an association of psychosis with sex.10 11 15 20 21 35 37 38 41 46 However, in other domains of neurological disease, there is evidence of female sex as a risk factor of psychosis. Comparing psychotic and non-psychotic epileptic patients, Taylor47 showed that female sex was a risk factor for development of psychosis. Our finding and those of others remain unexplained, and relevant factors involving genetic traits, as well as cultural and psychosocial involvements, should be investigated.

The multivariate analysis showed that the level of education was not an independent protection factor for psychosis. The association between psychosis and fewer years of education shown in the univariate analysis is likely to be an epiphenomenon which can be accounted for by the inverse correlation between the educational attainment and age and by the negative association between the level of education and female sex. Although one study13 reported that education was inversely related to psychosis, the results of our multivariate analysis agreed with most studies, which denied this effect.10 11 15 18 20 21 33 41

It has been postulated that patients with Alzheimer’s disease with and without the ε4 allele have distinguishing phenotypic characteristics.42 Ramachandran et al,22 in a preliminary report, showed that patients with Alzheimer’s disease and the ApoE ε3/4 genotype had more than a threefold increase in psychosis when compared with those with the ApoE ε3/3 genotype. As female patients with late onset Alzheimer’s disease carried the ε4 allele more often than did male patients,31 their finding might be attributable to the effects of sex and age. Lehtovirta et al,42Lopez-Alberola et al,48 and Lopez et al 49 showed no association between the ApoE ε4 gene and development of psychosis. In our study, in which other variables were concurrently examined, this association was clearly denied.

The present study showed that a subpopulation of patients with Alzheimer’s disease who are female, of late onset, of severe cognitive impairment, and of long duration of illness, have a high risk for development of psychosis. One possible explanation for our findings is that a particular subtype of Alzheimer’s disease which preferentially involves old women has distinctive clinical and neuropathological features. An alternative explanation is that characteristics including genetic, psychosocial, and environmental factors may affect development of psychosis in individuals. Further studies are needed to consider these hypotheses.


We thank Drs Hajime Kitagaki and Kazunari Ishii (Division of Neuroimaging Research) for their help in various parts of the study, and Yoko Takatsuki, Akitsugu Tokimasa, and Misato Fujimori (Neurorehabilitation Service) for their technical assistance.


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