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Intracranial venous and dural sinus thrombosis due to protein S deficiency in a patient with AIDS
  1. ALEJANDRO IRANZO
  1. Departments of Neurology
  2. Department of Internal Medicine, Hospital de de la Santa Creu i Sant Pau, Universitat Autónoma de Barcelona, Barcelona, Spain
  1. Dr Alex Iranzo, Servei de Neurologica, Hospital Clinic, C/Villarroel 170, Barcelona 08036, Spain. Telephone 34–3 2275413; fax 34–3-–2275454.
  1. PERE DOMINGO,
  2. JOSÉ CADAFALCH,
  3. MARÍA ANTONIA SAMBEAT
  1. Departments of Neurology
  2. Department of Internal Medicine, Hospital de de la Santa Creu i Sant Pau, Universitat Autónoma de Barcelona, Barcelona, Spain
  1. Dr Alex Iranzo, Servei de Neurologica, Hospital Clinic, C/Villarroel 170, Barcelona 08036, Spain. Telephone 34–3 2275413; fax 34–3-–2275454.

https://doi.org/10.1136/jnnp.64.5.688

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    Protein S is a vitamin K dependent plasma glycoprotein that inhibits blood coagulation through inactivating factors Va and VIIIa in cooperation with protein C. Deficiency of protein S, congenital or acquired, predisposes to thrombotic disease.

    In postmortem studies, the prevalence of cerebrovascular disease in HIV infected patients has ranged from 11% to 34%. The causes are diverse, and include embolic and thrombotic stroke, cerebral vasculitis, and cerebral haemorrhage.1Decreased free protein S has been commonly found in HIV infected adults and has been associated with systemic venous thrombosis.2

    To our knowledge, we report the first case of an HIV infected adult with intracranial dural sinuses and cerebral venous thrombosis due to protein S deficiency.

    A 37 year old HIV infected woman was admitted with severe and persistent headache of two weeks duration …

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