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About 30 cases of primary granulomatous hypophysitis have been reported, one third of them being asymptomatic in terms of sellar disease.1 2 The aetiology is not understood. The adenohypophysis alone or the whole pituitary gland may be involved.2 3 Clinical manifestation of primary granulomatous hypophysitis comprises hypopituitarism and local mass effect. In no symptomatic case reported so far, was the diagnosis suspected before surgery. There is also no experience on preoperative anti-inflammatory high dose corticosteroid therapy for primary granulomatous hypophysitis (PGH).
An otherwise healthy 16 year old girl presented with harmonic dwarfism (body length 1.34 m, body weight 31 kg), pubertas tarda (stage B2P2), and longstanding diabetes insipidus. Dynamic assessment of the adenohypophysis by a combined releasing hormone test …