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  • The hormonal response to stress is not modified by the dramatic decrease in prolactin plasma concentration during surgery for microprolactinoma

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The hormonal response to stress is not modified by the dramatic decrease in prolactin plasma concentration during surgery for microprolactinoma
  1. R Guieua,
  2. H Dufourb,
  3. C Devauxa,
  4. T Bruec,
  5. J P Rossoe,
  6. F Grisolib,
  7. M Grinof,
  8. A Enjalbertc,
  9. D Begoudd,
  10. N Broderd,
  11. H Rochata,
  12. P Jaquetc
  1. aLaboratoire de Biochimie, Faculté de Médecine Secteur Nord, UMR CNRS 6560, Institut Fédératif J Roche, Bd P Dramard 13015, Marseille, France, bService de Neurochirurgie, cService d’Endocrinologie, CHU Timone Adultes, dDépartement d’Anesthesie, CHU Timone, Bd J Moulin 13005, Marseille, France, eLabortatoire de Biochimie, fService d’Endocrinologie, Hopital Nord Bd P Dramard 13015, Marseille, France
  1. Dr R Guieu, Laboratoire de Biochimie, Faculté de Médecine Secteur Nord, UMR CNRS 6560, Institut Fédératif J Roche, Bd P Dramard 13015, Marseille, France. Fax 0033 04 91 65 75 95.

Abstract

OBJECTIIVES To determine the endocrine response to surgical stress in a homogeneous population of 36 women with microprolactinomas, particularly to evaluate the effect of the sharp decrease in plasma prolactin on stress induced hormonal secretion. In addition, the effects of exogenous opiates on prolactin secretion were studied.

METHODS The plasma kinetics of cortisol, prolactin, ACTH, GH, and β-endorphin like immunoreactivity (β-ELI) were analysed by including patients operated on with strict anaesthetic and surgical protocols, and by sampling blood every 10 minutes, starting at premedication up to 3 hours after induction.

RESULTS AND CONCLUSIONS (a) Surgical stress or opiate administration did not induce prolactin release in patients with microprolactinoma. (b) The dramatic decrease in prolactin concentrations have apparently no effect on the release of other hormones involved in stress. (c) The existence of an early GH peak, independently of any surgical procedure, strongly suggests that GH is released by surgical stress whereas β-endorphin is secreted in response to pain. Thus GH may be a useful marker of surgical stress.

  • anaesthesia
  • microprolactinomas
  • surgical stress
  • endorphins

https://doi.org/10.1136/jnnp.65.4.502

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