Article Text

Download PDFPDF
Medial temporal lobe atrophy in stroke patients: relation to pre-existing dementia
  1. H Hénona,b,
  2. F Pasquierb,
  3. I Durieua,
  4. J P Pruvoc,
  5. D Leysa
  1. aDepartment of Neurology, Stroke Unit, France, bDepartment of Neurology, Memory Clinic, cDepartment of Neuroradiology, Hôpital Roger Salengro, F-59037 Lille, France
  1. Dr Florence Pasquier, Department of Neurology, Memory unit, Hôpital Roger Salengro, F-59037 Lille, France. Telephone 0033 320 44 5785; fax 0033 320 44 6028; email pasquier{at}


OBJECTIVE The links between stroke and Alzheimer’s disease seem to be closer than expected by chance. In a previous study it was shown that up to 16% of patients admitted for stroke had pre-existing dementia. Medial temporal lobe atrophy (MTLA) is strongly associated with Alzheimer’s disease. The aim of this study was to determine the prevalence of MTLA and its relation with pre-existing dementia.

METHOD The study was conducted on 170 consecutive stroke patients (87 women; median age 75 years; 152 infarcts), who underwent non-contrast CT with temporal lobe oriented 2 mm contiguous slices at admission. A cut off point of 11.5 mm was used to differentiate patients with and without MTLA. Pre-existing dementia was assessed using the informant questionnaire on cognitive decline in the elderly (IQCODE) with a cut off score of 104.

RESULTS Ninety four patients (55.3%) had MTLA, of whom 23 (24.5%) had pre-existing dementia; of 76 patients without MTLA, only four (5.3%) had pre-existing dementia (p=0.0007). The logistic regression analysis with MTLA as dependent variable found the following independent variables: increasing age (p<0.05), and global cerebral atrophy scores (p<0.01). The IQCODE scores just reached significance (p=0.05).

CONCLUSION Stroke patients with MTLA are more likely to have pre-existing dementia; this suggests that Alzheimer’s disease might contribute to the dementia syndrome. A longitudinal follow up is now necessary to determine whether stroke patients with MTLA and without pre-existing dementia are at increased risk of Alzheimer’s disease over subsequent years.

  • stroke
  • dementia
  • medial temporal lobe atrophy

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.