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IgG anti-GT1a antibody which cross reacts with GQ1b ganglioside is associated with ophthalmoplegia in Guillain-Barré syndrome and in Fisher’s syndrome, a variant of Guillain-Barré syndrome.1 Pharyngeal-cervical-brachial weakness is another regional variant of Guillain-Barré syndrome originally described by Ropper.2 Its symptoms resemble those of botulism and diphtheria and are characterised by marked oropharyngeal, neck, and shoulder weakness with areflexia only in the arms. We report on a patient with this variant who had high titres of serum IgG anti-GT1a antibody which did not cross react with GQ1b.
A 55 year-old woman was admitted due to sudden onset ptosis, trouble with swallowing, and nausea and vomiting. One week before admission she had had an upper respiratory infection with diarrhoea which lasted for several days. On admission, …
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