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Intravenous immunoglobulin dependent inflammatory radiculopathy presenting as lumbar canal stenosis
  1. C E M HILLIER,
  2. J G LLEWELYN,
  3. M D HOURIHAN
  1. Departments of Neurology and Neuroradiology, University Hospital of Wales and University of Wales College of Medicine, Heath Park, Cardiff, UK
  1. Dr CEM Hillier, Department of Neurology, University Hospital of Wales, Heath Park, Cardiff CF4 4XW, UK. Telephone 0044 1222 746441; fax 0044 1222 744166.

https://doi.org/10.1136/jnnp.65.5.802

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    A patient with symptoms and signs of lumbar canal stenosis showed non-malignant, nerve root hypertrophy on MRI. The patient responded dramatically but temporarily to intravenous immunoglobulin (IVIg).

    Hypertrophy of nerve roots is recognised as a cause of “spinal stenosis” syndrome.1 The association has been previously described with hereditary causes such as neurofibromatosis, Refsum’s disease, and hereditary motor and sensory neuropathy (HSMN) type 1 and 3.2 There have been recent reports of chronic inflammatory demyelinating polyneuropathy (CIDP) presenting as a spinal stenosis syndrome.1 3 We report on a patient with an acquired inflammatory radiculopathy who presented with a lumbar canal stenosis syndrome only responsive to IVIg.

    A 60 year old white man presented with a 2 year history of progressive numbness and stiffness of his legs with difficulty in …

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