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Regional metabolism: associations with dyscalculia in Alzheimer’s disease
  1. Nobutsugu Hironoa,
  2. Etsuro Moria,
  3. Kazunari Ishiib,
  4. Toru Imamuraa,
  5. Tatsuo Shimomuraa,
  6. Satoshi Tanimukaia,
  7. Hiroaki Kazuia,
  8. Mamoru Hashimotoa,
  9. Hikari Yamashitaa,
  10. Masahiro Sasakib
  1. aDivision of Clinical Neurosciences, bDivision of Neuroimaging Research, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan
  1. Dr Nobutsugu Hirono, Division of Clinical Neuroscience, Hyogo Institute for Aging Brain and Cognitive Disorders, 520 Saisho-ko, Himeji 670-0981, Japan. Telephone 0081 792 95 5511; fax 0081 792 95 8199; email hirono{at}


OBJECTIVES The ability to calculate, which is an important aspect of social daily living, is commonly impaired in patients with Alzheimer’s disease even early in the course of the disease. Dyscalculia is often accompanied by focal brain damage, and has been argued to be an independent sign localised around the left temporoparietal region. However, the region most responsible for dyscalculia in Alzheimer’s disease has not been determined. The relation between calculation ability and regional cerebral glucose metabolism in Alzheimer’s disease was therefore examined.

METHODS The calculation ability, In 91 patients with probable Alzheimer’s disease of minimal to moderate severity, was assessed using the arithmetic subtest of the Wechsler adult intelligence scale-revised and the performance correlated with regional cerebral glucose metabolism determined by18F-fluorodeoxyglucose and PET.

RESULTS Regional glucose metabolism in the left inferior parietal lobule and in the left inferior temporal gyrus was significantly correlated with the calculation performance irrespective of age, sex, education, and severity of disease.

CONCLUSIONS The results suggest that dysfunction of the left inferior parietal lobule and the left inferior temporal gyrus plays an important part in producing dyscalculia in patients with Alzheimer’s disease.

  • calculation
  • Alzheimer’s disease
  • left inferior parietal lobule

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