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Antiganglioside antibodies in various episodes in a patient with recurrent Guillain-Barré syndrome
  1. Department of Neurology, Dokkyo University School of Medicine, Tochigi, Japan
  1. Dr Y Tagawa, Third Department of Internal Medicine, Kagawa Medical University, Ikenobe 1750–1, Miki, Kida, Kagawa 761–0793, Japan; fax: 81–87–891–2158, e-mail:ytagawa{at}

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Guillain-Barré syndrome is defined as an acute, monophasic polyneuropathy. It recurs in 2%-5% of patients.1 Both the initial and recurrent episodes are preceded by an infection. Antibodies against several gangliosides are often present in the acute phase in serum samples from patients with Guillain-Barré syndrome.2 There have been no previous reports, however, on anti-ganglioside antibodies in patients with recurrent disease. We report finding anti-ganglioside antibodies in a patient with recurrent Guillain-Barré syndrome during the third and fourth episodes.

Ten days after a bout of upper respiratory tract infection, a 26 year old man noted paraesthesias in his fingers and toes, and rapidly developed limb weakness. He had bulbar palsy and areflexic tetraparesis on day 1, and underwent three sessions of plasmapheresis on days 3, …

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