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Differences in duration of Huntington’s disease based on age at onset
  1. Tatiana Foroud,
  2. Jacqueline Gray,
  3. Julia Ivashina,
  4. P Michael Conneally
  1. Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA
  1. Department of Medical and Molecular Genetics, Indiana University School of Medicine, Medical Research and Library Building, IB 155, 975 W Walnut Street, Indianapolis, IN 46202, USA. Telephone 001 317 278 1291; fax 001 317 274 2387; email foroud{at}medgen.iupui.edu

Abstract

OBJECTIVES Data from a sample of 2494 patients affected with Huntington’s disease (HD), collected as part of the National Research Roster for Huntington Disease Patients and Families, were examined to determine if there was a relation between age at onset and duration of illness.

METHODS Sufficient data for inclusion in analysis was available from 2068 patients, of whom 828 were deceased and 1240 were living. The median duration of disease was 21.4 years with a range of 1.2 to 40.8 years. Patients were categorised into one of four groups based on their age at onset.

RESULTS Significant differences in duration based on the age at onset were found (p<0.025), with juvenile and late onset patients with HD having shorter duration of illness compared with those with an onset between 20–49 years.

CONCLUSIONS Duration of disease is influenced by the age at symptom onset with juvenile and late onset patients having the shortest duration.

  • Huntington’s disease
  • duration
  • age at onset

https://doi.org/10.1136/jnnp.66.1.52

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