The cholinergic hypothesis of Alzheimer’s disease: a review of progress

Paul T Francis; Alan M Palmer; Michael Snape; Gordon K Wilcock

doi:10.1136/jnnp.66.2.137

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The cholinergic hypothesis of Alzheimer’s disease: a review of progress

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Online download statistics by month: March 1999 to March 2023

	Abstract	Full	Pdf
Mar 1999	18	90	41
Apr 1999	22	175	124
May 1999	25	315	64
Jun 1999	11	132	64
Jul 1999	24	91	30
Aug 1999	13	56	15
Sep 1999	23	114	50
Oct 1999	16	138	62
Nov 1999	33	125	40
Dec 1999	14	132	43
Jan 2000	28	158	55
Feb 2000	20	138	52
Mar 2000	17	189	61
Apr 2000	25	148	68
May 2000	12	116	68
Jun 2000	6	57	43
Jul 2000	9	57	32
Aug 2000	6	67	46
Sep 2000	6	57	32
Oct 2000	10	84	44
Nov 2000	11	92	58
Dec 2000	16	61	58
Jan 2001	13	60	37
Feb 2001	8	80	43
Mar 2001	10	97	52
Apr 2001	18	122	54
May 2001	11	83	42
Jun 2001	10	48	32
Jul 2001	8	57	57
Aug 2001	7	50	20
Sep 2001	8	105	36
Oct 2001	12	120	49
Nov 2001	13	87	54
Dec 2001	11	67	31
Jan 2002	12	63	35
Feb 2002	12	48	52
Mar 2002	13	89	153
Apr 2002	11	60	58
May 2002	18	84	109
Jun 2002	11	58	39
Jul 2002	11	48	39
Aug 2002	13	58	65
Sep 2002	13	47	23
Oct 2002	16	68	55
Nov 2002	6	42	43
Dec 2002	6	61	39
Jan 2003	11	56	51
Feb 2003	7	64	41
Mar 2003	26	95	86
Apr 2003	14	114	77
May 2003	12	61	61
Jun 2003	12	52	41
Jul 2003	4	37	59
Aug 2003	7	38	21
Sep 2003	8	60	40
Oct 2003	24	63	53
Nov 2003	11	90	69
Dec 2003	15	69	77
Jan 2004	20	61	39
Feb 2004	12	98	76
Mar 2004	20	97	74
Apr 2004	29	77	71
May 2004	15	58	65
Jun 2004	17	59	46
Jul 2004	59	132	59
Aug 2004	53	126	26
Sep 2004	30	140	69
Oct 2004	50	285	65
Nov 2004	46	248	98
Dec 2004	40	270	126
Jan 2005	47	250	90
Feb 2005	57	265	103
Mar 2005	44	247	128
Apr 2005	36	236	120
May 2005	42	186	115
Jun 2005	33	101	60
Jul 2005	25	104	86
Aug 2005	38	185	88
Sep 2005	11	171	70
Oct 2005	38	195	86
Nov 2005	57	225	110
Dec 2005	50	151	70
Jan 2006	24	212	94
Feb 2006	28	168	75
Mar 2006	20	238	86
Apr 2006	111	230	116
May 2006	159	169	105
Jun 2006	92	105	71
Jul 2006	68	96	60
Aug 2006	80	78	45
Sep 2006	115	102	90
Oct 2006	163	168	120
Nov 2006	187	260	161
Dec 2006	119	128	94
Jan 2007	107	146	116
Feb 2007	133	163	95
Mar 2007	199	247	140
Apr 2007	232	288	174
May 2007	132	273	162
Jun 2007	69	123	66
Jul 2007	103	122	83
Aug 2007	66	140	81
Sep 2007	65	320	64
Oct 2007	105	244	114
Nov 2007	136	272	149
Dec 2007	86	166	84
Jan 2008	78	140	133
Feb 2008	108	206	126
Mar 2008	140	222	157
Apr 2008	161	324	187
May 2008	112	234	126
Jun 2008	80	169	62
Jul 2008	72	138	78
Aug 2008	52	106	56
Sep 2008	71	129	66
Oct 2008	88	168	84
Nov 2008	162	296	126
Dec 2008	75	236	87
Jan 2009	96	219	94
Feb 2009	138	212	112
Mar 2009	145	315	128
Apr 2009	145	324	140
May 2009	124	271	151
Jun 2009	87	164	97
Jul 2009	66	142	50
Aug 2009	60	133	63
Sep 2009	76	174	73
Oct 2009	88	297	105
Nov 2009	152	385	139
Dec 2009	161	350	108
Jan 2010	184	283	105
Feb 2010	210	256	104
Mar 2010	227	469	140
Apr 2010	116	653	162
May 2010	132	612	145
Jun 2010	96	396	120
Jul 2010	98	247	63
Aug 2010	81	340	90
Sep 2010	73	445	80
Oct 2010	109	514	146
Nov 2010	127	631	139
Dec 2010	129	443	76
Jan 2011	96	352	79
Feb 2011	103	435	80
Mar 2011	163	594	195
Apr 2011	116	409	150
May 2011	111	352	134
Jun 2011	121	362	96
Jul 2011	166	124	50
Aug 2011	213	58	36
Sep 2011	235	88	38
Oct 2011	271	159	71
Nov 2011	253	351	92
Dec 2011	51	476	124
Jan 2012	45	401	93
Feb 2012	49	392	76
Mar 2012	43	515	103
Apr 2012	41	594	129
May 2012	42	558	101
Jun 2012	45	443	85
Jul 2012	36	445	91
Aug 2012	40	422	104
Sep 2012	61	504	105
Oct 2012	76	786	130
Nov 2012	78	907	151
Dec 2012	71	720	130
Jan 2013	62	715	109
Feb 2013	75	979	155
Mar 2013	117	1080	157
Apr 2013	255	1399	247
May 2013	221	993	218
Jun 2013	99	493	118
Jul 2013	108	476	102
Aug 2013	144	604	137
Sep 2013	190	723	135
Oct 2013	254	1071	194
Nov 2013	292	1481	224
Dec 2013	199	946	185
Jan 2014	160	704	154
Feb 2014	121	848	141
Mar 2014	101	1068	207
Apr 2014	102	1404	175
May 2014	89	1340	279
Jun 2014	70	760	124
Jul 2014	96	695	101
Aug 2014	53	467	92
Sep 2014	90	727	142
Oct 2014	103	450	72
Nov 2014	131	463	95
Dec 2014	102	386	81
Jan 2015	96	421	70
Feb 2015	261	526	138
Mar 2015	280	1066	200
Apr 2015	367	981	227
May 2015	211	914	205
Jun 2015	164	551	124
Jul 2015	158	526	106
Aug 2015	172	598	113
Sep 2015	199	658	121
Oct 2015	154	524	109
Nov 2015	289	951	201
Dec 2015	195	740	146
Jan 2016	189	607	161
Feb 2016	216	615	133
Mar 2016	302	903	205
Apr 2016	398	1119	208
May 2016	239	976	177
Jun 2016	257	740	138
Jul 2016	180	408	157
Aug 2016	155	518	103
Sep 2016	201	604	96
Oct 2016	289	846	183
Nov 2016	338	941	239
Dec 2016	266	680	150
Jan 2017	258	1010	166
Feb 2017	222	1080	190
Mar 2017	275	1130	233
Apr 2017	223	1019	195
May 2017	148	793	184
Jun 2017	177	444	134
Jul 2017	423	319	104
Aug 2017	607	439	123
Sep 2017	743	517	106
Oct 2017	1019	666	161
Nov 2017	1235	828	302
Dec 2017	808	534	187
Jan 2018	779	524	193
Feb 2018	892	564	187
Mar 2018	1162	694	244
Apr 2018	1421	796	226
May 2018	996	683	205
Jun 2018	617	440	129
Jul 2018	649	491	125
Aug 2018	594	432	116
Sep 2018	834	579	297
Oct 2018	1084	749	690
Nov 2018	1122	756	719
Dec 2018	910	684	672
Jan 2019	807	542	559
Feb 2019	878	549	664
Mar 2019	906	580	718
Apr 2019	1035	665	823
May 2019	954	644	738
Jun 2019	528	363	651
Jul 2019	616	433	808
Aug 2019	544	366	373
Sep 2019	605	416	341
Oct 2019	826	600	184
Nov 2019	914	657	208
Dec 2019	641	507	170
Jan 2020	612	462	130
Feb 2020	771	668	145
Mar 2020	581	429	161
Apr 2020	757	604	193
May 2020	941	681	212
Jun 2020	483	365	173
Jul 2020	345	286	93
Aug 2020	365	267	100
Sep 2020	665	520	124
Oct 2020	656	448	135
Nov 2020	858	611	197
Dec 2020	621	446	180
Jan 2021	742	563	203
Feb 2021	801	532	223
Mar 2021	782	530	199
Apr 2021	791	593	183
May 2021	633	567	217
Jun 2021	404	410	145
Jul 2021	442	451	157
Aug 2021	535	542	140
Sep 2021	516	524	148
Oct 2021	782	591	270
Nov 2021	883	680	222
Dec 2021	795	597	145
Jan 2022	783	651	203
Feb 2022	670	507	132
Mar 2022	942	784	260
Apr 2022	958	784	198
May 2022	965	811	226
Jun 2022	602	519	108
Jul 2022	496	422	65
Aug 2022	487	404	112
Sep 2022	736	607	149
Oct 2022	831	703	136
Nov 2022	901	766	118
Dec 2022	706	536	171
Jan 2023	749	612	134
Feb 2023	837	699	119
Total	72586	115958	39494

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