Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Schilder’s disease or myelinoclastic diffuse sclerosis is a rare acute or subacute demyelinating disorder which primarily affects children and young adults.1 2 We report the clinical and neuroradiological follow up of two boys affected by a demyelinating disease with a prolonged relapsing-remitting course, response to corticosteroids, and relatively good long term prognosis.
The first patient presented at the age of 12 with a 2 month history of repeated episodes of headache and blurred vision followed by weakness in the left leg, lasting a few hours. Head CT and bilateral carotid angiography were normal. Two weeks later the left hemiparesis and headache recurred. T2 weighted images on brain MRI disclosed a hyperintense signal in the right parieto-occipital white matter of the centrum semiovale, without a mass effect. Flash visual evoked stimuli elicited a decreased potential on the left side. Motor and sensory nerve conduction were normal. Corticosteroid treatment (prednisone (1mg/kg/day)) reversed the clinical symptoms. At the age of 14, …