You are here

Article Text

Article menu
Download PDFPDF
Letters to the editor
In vivo cerebral proton MRS in a case of subacute sclerosing panencephalitis
  1. A M SALVAN,
  2. S CONFORT-GOUNY,
  3. P J COZZONE,
  4. J VION-DURY
  1. Centre de Résonance Magnétique Biologique et Médicale (CRMBM), UMR CNRS 6612, Faculté de Médecine, 27 Bd J. Moulin, 13005 Marseille, France
  2. Service de Neuropédiatrie, Hôpital d’Enfants, CHU Timone, Rue St Pierre, 13005 Marseille, France
  1. Dr Jean Vion-Dury, Centre de Résonance Magnétique Biologique et Médicale (CRMBM), UMR CNRS 6612, Faculté de Médecine, 27 Bd J. Moulin, 13005 Marseille, France. Telephone 0033 4 91 32 42 15; fax 0033 4 91 25 65 39; emailviondury{at}medecine.univ-mrs.fr
  1. B CHABROL,
  2. J MANCINI
  1. Centre de Résonance Magnétique Biologique et Médicale (CRMBM), UMR CNRS 6612, Faculté de Médecine, 27 Bd J. Moulin, 13005 Marseille, France
  2. Service de Neuropédiatrie, Hôpital d’Enfants, CHU Timone, Rue St Pierre, 13005 Marseille, France
  1. Dr Jean Vion-Dury, Centre de Résonance Magnétique Biologique et Médicale (CRMBM), UMR CNRS 6612, Faculté de Médecine, 27 Bd J. Moulin, 13005 Marseille, France. Telephone 0033 4 91 32 42 15; fax 0033 4 91 25 65 39; emailviondury{at}medecine.univ-mrs.fr

https://doi.org/10.1136/jnnp.66.4.547

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    (A and C) Location of the 2 spectroscopic volumes of interest (VOI = 2×2×2 cm) displayed on T2 weighted MRI showing asymmetric frontal white matter hypersignals. (B) Short echo STEAM spectra obtained from the frontal brain lesion and (D) from the parieto-occipital brain lesion in the patient with SSPE. Ins=myoinositol (3.54 ppm), Tau=taurine/scylloinositol (3.33 ppm), Cho=choline containing compounds (3.20 ppm), Cr-PCr=creatine/phosphocreatine (3.04 ppm), Glx=glutamate-glutamine (2.10–2.45 ppm), NAA=N-acetylaspartate (2.02 ppm), Lip=lipids and/or proteins (between 1.5 and 0.2 ppm).

    Subacute sclerosing panencephalitis (SSPE) is a rare encephalopathy caused by persistent defective measles virus in the CNS. Brain lesions may involve all regions of the CNS. The pathophysiological events associated with the disease are characterised by a perivascular infiltration by monocytes and astrocytic proliferation, neuronal degeneration, and demyelination.1 The exploration of SSPE by brain proton magnetic resonance spectroscopy (MRS) might be of interest to evaluate the extent of the metabolic lesions across the brain. We report here cerebral MRS findings in a 17 year old boy with SSPE.

    The first symptoms—difficulties at school—appeared at the age of 16. Six months later, abnormal movements occurred. The symptoms progressed rapidly over the next 2 months with myoclonic …

    View Full Text