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Subthalamic nucleus stimulation improves directly levodopa induced dyskinesias in Parkinson’s disease
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  1. ROBERTO FIGUEIRAS-MÉNDEZ
  1. Unit of Functional Neurosurgery, Clínica Nuestra Señora del Rosario, Madrid, Spain
  2. Department of Neurosurgery, Centro Especial Ramón y Cajal, Madrid, Spain
  3. Unit of Functional Neurosurgery, Clínica Nuestra Señora del Rosario, Madrid, Spain
  4. Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain
  5. Hospital “Príncipe de Asturias”, Universidad de Alcalá de Henares, Madrid, Spain
  6. Unit of Neurophysiology
  7. Unit of Radiology, Clínica Nuestra Señora del Rosario, Madrid, Spain
  1. Dr Félix Javier Jiménez-Jiménez, C/Corregidor José de Pasamonte 24, 3º D, E-28030 Madrid, Spain. Telephone 0034 91 4376078; fax 0034 91 3280704; emailFjimenezj{at}meditex.es
  1. FERNANDO MARÍN-ZARZA
  1. Unit of Functional Neurosurgery, Clínica Nuestra Señora del Rosario, Madrid, Spain
  2. Department of Neurosurgery, Centro Especial Ramón y Cajal, Madrid, Spain
  3. Unit of Functional Neurosurgery, Clínica Nuestra Señora del Rosario, Madrid, Spain
  4. Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain
  5. Hospital “Príncipe de Asturias”, Universidad de Alcalá de Henares, Madrid, Spain
  6. Unit of Neurophysiology
  7. Unit of Radiology, Clínica Nuestra Señora del Rosario, Madrid, Spain
  1. Dr Félix Javier Jiménez-Jiménez, C/Corregidor José de Pasamonte 24, 3º D, E-28030 Madrid, Spain. Telephone 0034 91 4376078; fax 0034 91 3280704; emailFjimenezj{at}meditex.es
  1. JOSÉ ANTONIO MOLINA
  1. Unit of Functional Neurosurgery, Clínica Nuestra Señora del Rosario, Madrid, Spain
  2. Department of Neurosurgery, Centro Especial Ramón y Cajal, Madrid, Spain
  3. Unit of Functional Neurosurgery, Clínica Nuestra Señora del Rosario, Madrid, Spain
  4. Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain
  5. Hospital “Príncipe de Asturias”, Universidad de Alcalá de Henares, Madrid, Spain
  6. Unit of Neurophysiology
  7. Unit of Radiology, Clínica Nuestra Señora del Rosario, Madrid, Spain
  1. Dr Félix Javier Jiménez-Jiménez, C/Corregidor José de Pasamonte 24, 3º D, E-28030 Madrid, Spain. Telephone 0034 91 4376078; fax 0034 91 3280704; emailFjimenezj{at}meditex.es
  1. FÉLIX JAVIER JIMÉNEZ-JIMÉNEZ,
  2. MIGUEL ORTÍ-PAREJA
  1. Unit of Functional Neurosurgery, Clínica Nuestra Señora del Rosario, Madrid, Spain
  2. Department of Neurosurgery, Centro Especial Ramón y Cajal, Madrid, Spain
  3. Unit of Functional Neurosurgery, Clínica Nuestra Señora del Rosario, Madrid, Spain
  4. Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain
  5. Hospital “Príncipe de Asturias”, Universidad de Alcalá de Henares, Madrid, Spain
  6. Unit of Neurophysiology
  7. Unit of Radiology, Clínica Nuestra Señora del Rosario, Madrid, Spain
  1. Dr Félix Javier Jiménez-Jiménez, C/Corregidor José de Pasamonte 24, 3º D, E-28030 Madrid, Spain. Telephone 0034 91 4376078; fax 0034 91 3280704; emailFjimenezj{at}meditex.es
  1. CARLOS MAGARIÑOS
  1. Unit of Functional Neurosurgery, Clínica Nuestra Señora del Rosario, Madrid, Spain
  2. Department of Neurosurgery, Centro Especial Ramón y Cajal, Madrid, Spain
  3. Unit of Functional Neurosurgery, Clínica Nuestra Señora del Rosario, Madrid, Spain
  4. Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain
  5. Hospital “Príncipe de Asturias”, Universidad de Alcalá de Henares, Madrid, Spain
  6. Unit of Neurophysiology
  7. Unit of Radiology, Clínica Nuestra Señora del Rosario, Madrid, Spain
  1. Dr Félix Javier Jiménez-Jiménez, C/Corregidor José de Pasamonte 24, 3º D, E-28030 Madrid, Spain. Telephone 0034 91 4376078; fax 0034 91 3280704; emailFjimenezj{at}meditex.es
  1. MIGUEL ANGEL LÓPEZ-PINO,
  2. VICENTE MARTÍNEZ
  1. Unit of Functional Neurosurgery, Clínica Nuestra Señora del Rosario, Madrid, Spain
  2. Department of Neurosurgery, Centro Especial Ramón y Cajal, Madrid, Spain
  3. Unit of Functional Neurosurgery, Clínica Nuestra Señora del Rosario, Madrid, Spain
  4. Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain
  5. Hospital “Príncipe de Asturias”, Universidad de Alcalá de Henares, Madrid, Spain
  6. Unit of Neurophysiology
  7. Unit of Radiology, Clínica Nuestra Señora del Rosario, Madrid, Spain
  1. Dr Félix Javier Jiménez-Jiménez, C/Corregidor José de Pasamonte 24, 3º D, E-28030 Madrid, Spain. Telephone 0034 91 4376078; fax 0034 91 3280704; emailFjimenezj{at}meditex.es

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Bilateral chronic subthalamic nucleus (STN) stimulation is a new and useful surgical method to improve parkinsonian disability. The improvement involves all the major parkinsonian signs.1Recently, Krack et al 2 reported that chronic stimulation of the STN also improved levodopa induced dyskinesias, although they explained this effect mainly by a decrease in the levodopa dosage. We report on a patient who presented a marked improvement of levodopa induced dyskinesias without decreasing the daily dosage of levodopa.

A 68 year old man was diagnosed with Parkinson’s disease at the age of 38, and started levodopa at the age of 43, with good initial effect. At the age of 56 …

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