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Creutzfeldt-Jakob-like syndrome induced by lithium, levomepromazine, and phenobarbitone
  1. HIDEYUKI KIKYO
  1. Shemaron 201, 3–12–28 Negishi, Taito-ku
  2. Tokyo 110, Japan
  3. 1–5–45 Yushima Bunkyo-ku, Tokyo 113, Japan
  1. Dr Hideyuki Kikyo, Department of Neurology, Tokyo Medical and Dental University, Tokyo, Japan. email:kikyo{at}m.u-tokyo.ac.jp
  1. TETSUO FURUKAWA
  1. Shemaron 201, 3–12–28 Negishi, Taito-ku
  2. Tokyo 110, Japan
  3. 1–5–45 Yushima Bunkyo-ku, Tokyo 113, Japan
  1. Dr Hideyuki Kikyo, Department of Neurology, Tokyo Medical and Dental University, Tokyo, Japan. email:kikyo{at}m.u-tokyo.ac.jp

https://doi.org/10.1136/jnnp.66.6.802

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    Creutzfeldt-Jakob-like syndrome was first reported by Smith and Kocen1 in 1988. Its symptoms resemble Creutzfeldt-Jakob disease but it is induced by drugs, particularly lithium, and most patients recover without sequel after discontinuation of drugs. It also displays a characteristic EEG similar to Creutzfeldt-Jakob disease, but this returns to normal when the patient recovers.

    There have been some case reports of Creutzfeldt-Jakob-like syndrome after that of Smith et al (table), but no paper seems to have described the detailed course of EEG changes. This paper presents a case of Creutzfeldt-Jakob-like syndrome possibly induced by lithium, levomepromazine, and phenobarbitone, in which we succeeded in recording the course of EEG changes.

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