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Spontaneous intralesional haemorrhage in dysembryoplastic neuroepithelial tumours: a series of five cases
  1. Maria Thoma,
  2. Beatriz Gomez-Ansonb,
  3. Tamas Revesza,
  4. William Harknessc,
  5. Ciaran J O’Briend,
  6. Rupert Kett-Whitee,
  7. E Wyn Jonesf,
  8. John Stevensb,
  9. Francesco Scaravillia
  1. aDepartment of Neuropathology, bDepartment of Neuroradiology, cDepartment of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, dDepartment of Histopathology, eDepartment of Neurosurgery, fDepartment of Neuroradiology, Morriston Hospital, Swansea, UK
  1. Dr Maria Thom, Department of Neuropathology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK. Telephone 0044 171 837 3611; fax 0044 171 916 9546.

Abstract

Five patients with dysembryoplastic neuroepithelial tumour (DNT) showing extensive secondary haemorrhage, a finding not previously associated with these neoplasms, are described. The clinical presentations, neuroimaging findings, and histopathological features of these patients are reviewed. One patient, a previously asymptomatic 12 year old girl, presented with an acute intracerebral haemorrhage into a DNT. A further four young adults with histories of intractable partial and generalised seizures dating from childhood showed significant chronic haemorrhages within DNT, the MRI appearances in one patient giving a false impression of a cavernoma. Histopathology disclosed vascular abnormalities within these tumours which, together with other factors discussed, may have predisposed these tumours to haemorrhage.

  • DNT
  • epilepsy
  • hemorrhage
  • MRI
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