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Human herpesvirus 6 is latent in peripheral blood of patients with relapsing-remitting multiple sclerosis
  1. Antonella Rotolaa,
  2. Enzo Cassaia,
  3. Maria Rosaria Tolab,
  4. Enrico Granierib,
  5. Dario Di Lucaa
  1. aDepartments of Experimental and Diagnostic Medicine, Section of Microbiology, bMedical and Surgical Disciplines, Section of Neurology, University of Ferrara, Italy
  1. Dr Dario Di Luca, Dept Experimental and Diagnostic Medicine, Section of Microbiology, Via Luigi Borsari 46, 44100 Ferrara, Italy. Telephone 0039 0532 291408; fax 0039 0532 247618; emaildil{at}


Studies of the association between HHV-6 and multiple sclerosis are hindered by the difficulty in discriminating between latent and active infection. A follow up study was undertaken of patients with multiple sclerosis, searching peripheral blood mononuclear cells for molecular markers associated with HHV-6 latency and lytic replication. The results show that HHV-6 is latent and did not support systemic infection in patients with multiple sclerosis. Likewise, patients with multiple sclerosis did not show any evidence of active infection with other human herpesviruses HHV-7 and HHV-8.

  • multiple sclerosis
  • HHV-6
  • transcription

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