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Neuronal activity alters local blood flow in brain tumour adjacent to the activating cortex
  1. KAORU SAKATANI,
  2. HUANCONG ZUO,
  3. YENG WANG
  1. Department of Neurosurgery, China-Japan Friendship Hospital, Beijing, China
  2. Group of Detection and Analysis of Human Body Movement, Program of BME, Department of Electrical Engineering, Tsinghua University, Japan
  3. Department of Rehabilitation, Takahashi Neurosurgical Hospital, Japan
  1. Dr Kaoru Sakatani, Department of Neurosurgery, China-Japan Friendship Hospital, Yinghua East Rd., Hepingli, Beijing 100029, People’s Republic of China. Telephone (fax) 0086 10 64203246; email sakatani{at}public.east.cn.net
  1. WEMARA LICHTY
  1. Department of Neurosurgery, China-Japan Friendship Hospital, Beijing, China
  2. Group of Detection and Analysis of Human Body Movement, Program of BME, Department of Electrical Engineering, Tsinghua University, Japan
  3. Department of Rehabilitation, Takahashi Neurosurgical Hospital, Japan
  1. Dr Kaoru Sakatani, Department of Neurosurgery, China-Japan Friendship Hospital, Yinghua East Rd., Hepingli, Beijing 100029, People’s Republic of China. Telephone (fax) 0086 10 64203246; email sakatani{at}public.east.cn.net
  1. KIYOMI YABU
  1. Department of Neurosurgery, China-Japan Friendship Hospital, Beijing, China
  2. Group of Detection and Analysis of Human Body Movement, Program of BME, Department of Electrical Engineering, Tsinghua University, Japan
  3. Department of Rehabilitation, Takahashi Neurosurgical Hospital, Japan
  1. Dr Kaoru Sakatani, Department of Neurosurgery, China-Japan Friendship Hospital, Yinghua East Rd., Hepingli, Beijing 100029, People’s Republic of China. Telephone (fax) 0086 10 64203246; email sakatani{at}public.east.cn.net

https://doi.org/10.1136/jnnp.67.4.553

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    Characteristics of blood flow in brain tumours have been studied extensively1; these studies are important for diagnosis of malignancy and therapy monitoring. Our study is the first to consider how activity dependent changes of regional cerebral blood flow (rCBF) alter tumour blood flow in the brain tumour adjacent to the activating cortex. Such an interaction between cortical blood flow and tumour blood flow may be of value for evaluating mechanisms of neurological symptoms associated with brain tumours.

    Neuronal activation causes an increase of regional cerebral blood flow (rCBF) in the activating cortical area.2 Near infrared spectroscopy (NIRS) demonstrates the increase in rCBF during neuronal activity as increases in oxygenated haemoglobin (oxy-Hb) and total haemoglobin (total-Hb) with a decrease in deoxyhaemoglobin (deoxy-Hb)3-5; NIRS is an optical method to measure concentration changes of oxy-Hb, deoxy-Hb, and total-Hb (oxy-Hb+deoxy-Hb) in cerebral vessels by means of the characteristic absorption spectra of haemoglobin in the near infrared range.

    In the present study, we measured changes of oxygenation and haemodynamics in the brain tumour adjacent to the activating cortex by means of NIRS. We found transient decreases in oxy-Hb and total-Hb in the …

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