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Characteristics of blood flow in brain tumours have been studied extensively1; these studies are important for diagnosis of malignancy and therapy monitoring. Our study is the first to consider how activity dependent changes of regional cerebral blood flow (rCBF) alter tumour blood flow in the brain tumour adjacent to the activating cortex. Such an interaction between cortical blood flow and tumour blood flow may be of value for evaluating mechanisms of neurological symptoms associated with brain tumours.
Neuronal activation causes an increase of regional cerebral blood flow (rCBF) in the activating cortical area.2 Near infrared spectroscopy (NIRS) demonstrates the increase in rCBF during neuronal activity as increases in oxygenated haemoglobin (oxy-Hb) and total haemoglobin (total-Hb) with a decrease in deoxyhaemoglobin (deoxy-Hb)3-5; NIRS is an optical method to measure concentration changes of oxy-Hb, deoxy-Hb, and total-Hb (oxy-Hb+deoxy-Hb) in cerebral vessels by means of the characteristic absorption spectra of haemoglobin in the near infrared range.
In the present study, we measured changes of oxygenation and haemodynamics in the brain tumour adjacent to the activating cortex by means of NIRS. We found transient decreases in oxy-Hb and total-Hb in the …