Clear reports a case of anaphylactoid reaction to methylprednisolone which developed after starting treatment with interferon β-1b. She states that “allergic reaction to steroids is rare and anaphylactoid reaction to methylprednisolone rarer still with only three reports in the literature.”1 Her report surprised us as on the week of publication of her case we had a patient with multiple sclerosis who developed an urticarial rash within 15 minutes of commencing treatment with intravenous methylprednisolone. Although we thought this to be an unusual response …