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Focal neuropathy associated with cutaneous necrosis at the site of interferon-β injection for multiple sclerosis
  1. ALAIN CRÉANGE
  1. Service de Neurologie, Centre Hospitalier Universitaire Henri Mondor, Créteil, France
  2. Service de Physiologie-Explorations Fonctionnelles
  1. Dr Alain Créange, Service de Neurologie, Centre Hospitalier Universitaire Henri Mondor, 94010 Créteil Cedex, France email creange{at}univ-paris12.fr
  1. JEAN-PASCAL LEFAUCHEUR
  1. Service de Neurologie, Centre Hospitalier Universitaire Henri Mondor, Créteil, France
  2. Service de Physiologie-Explorations Fonctionnelles
  1. Dr Alain Créange, Service de Neurologie, Centre Hospitalier Universitaire Henri Mondor, 94010 Créteil Cedex, France email creange{at}univ-paris12.fr

https://doi.org/10.1136/jnnp.68.3.395

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    Interferon-β is the first approved treatment for relapsing multiple sclerosis. Although generally well tolerated, it is sometimes associated with cutaneous reactions at the injection site. To decrease local side effects, it has been suggested that injection sites in the belly, the thigh, and the arms are regularly changed. These cutaneous reactions range from slight erythema to necrosis. We report the first mononeuropathy associated with local adverse reaction after interferon-β injection.

    A 39 year old woman had a 15 year history of multiple sclerosis, and a 3 year history of secondary progressive phase (EDSS=6). She had been treated for 3 years with …

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