Disability outcome measures in therapeutic trials of relapsing-remitting multiple sclerosis: effects of heterogeneity of disease course in placebo cohorts

Clarence Liu; Lance D Blumhardt

doi:10.1136/jnnp.68.4.450

Article metrics

Paper

Disability outcome measures in therapeutic trials of relapsing-remitting multiple sclerosis: effects of heterogeneity of disease course in placebo cohorts

Free

Online download statistics by month:

Online download statistics by month: March 2000 to March 2023

	Abstract	Full	Pdf
Mar 2000	33	72	23
Apr 2000	37	52	12
May 2000	42	24	12
Jun 2000	14	15	11
Jul 2000	7	12	10
Aug 2000	6	11	13
Sep 2000	8	14	1
Oct 2000	16	12	10
Nov 2000	12	19	5
Dec 2000	6	7	6
Jan 2001	3	12	5
Feb 2001	10	13	11
Mar 2001	2	18	5
Apr 2001	8	19	0
May 2001	0	10	0
Jun 2001	1	24	0
Jul 2001	3	23	5
Aug 2001	4	11	2
Sep 2001	1	22	3
Oct 2001	4	10	8
Nov 2001	4	29	4
Dec 2001	2	10	0
Jan 2002	2	12	1
Feb 2002	2	14	7
Mar 2002	6	28	2
Apr 2002	5	12	2
May 2002	4	12	1
Jun 2002	3	10	3
Jul 2002	3	8	4
Aug 2002	5	7	4
Sep 2002	1	21	8
Oct 2002	3	15	5
Nov 2002	6	26	18
Dec 2002	4	13	9
Jan 2003	2	12	11
Feb 2003	6	17	12
Mar 2003	3	17	12
Apr 2003	3	6	7
May 2003	4	12	16
Jun 2003	3	14	9
Jul 2003	2	11	12
Aug 2003	2	7	7
Sep 2003	6	28	15
Oct 2003	3	18	5
Nov 2003	0	3	0
Dec 2003	1	8	4
Jan 2004	1	4	2
Feb 2004	2	6	5
Mar 2004	3	6	2
Apr 2004	2	7	8
May 2004	1	4	5
Jun 2004	8	16	7
Jul 2004	51	56	15
Aug 2004	41	56	18
Sep 2004	27	43	13
Oct 2004	11	18	3
Nov 2004	13	42	6
Dec 2004	24	26	5
Jan 2005	20	53	18
Feb 2005	39	43	16
Mar 2005	23	59	33
Apr 2005	9	43	6
May 2005	8	31	18
Jun 2005	15	18	11
Jul 2005	14	23	10
Aug 2005	13	37	17
Sep 2005	11	15	16
Oct 2005	30	32	17
Nov 2005	12	31	6
Dec 2005	15	31	6
Jan 2006	20	32	8
Feb 2006	19	29	14
Mar 2006	11	42	25
Apr 2006	15	22	8
May 2006	17	12	6
Jun 2006	12	12	7
Jul 2006	13	17	13
Aug 2006	16	8	6
Sep 2006	13	15	6
Oct 2006	6	15	10
Nov 2006	16	23	17
Dec 2006	12	10	11
Jan 2007	14	16	12
Feb 2007	14	26	12
Mar 2007	27	18	17
Apr 2007	19	10	11
May 2007	13	7	9
Jun 2007	11	3	2
Jul 2007	22	9	3
Aug 2007	15	6	9
Sep 2007	14	11	9
Oct 2007	17	3	8
Nov 2007	14	8	8
Dec 2007	14	3	7
Jan 2008	17	7	8
Feb 2008	19	7	6
Mar 2008	24	2	2
Apr 2008	20	4	2
May 2008	24	3	6
Jun 2008	13	2	3
Jul 2008	8	1	4
Aug 2008	15	3	2
Sep 2008	12	2	2
Oct 2008	19	3	5
Nov 2008	17	5	3
Dec 2008	5	2	4
Jan 2009	19	3	3
Feb 2009	17	0	2
Mar 2009	14	0	3
Apr 2009	18	7	3
May 2009	12	3	3
Jun 2009	15	4	7
Jul 2009	12	2	1
Aug 2009	19	4	5
Sep 2009	12	11	7
Oct 2009	19	2	3
Nov 2009	11	1	3
Dec 2009	13	3	2
Jan 2010	16	0	1
Feb 2010	15	5	6
Mar 2010	11	2	2
Apr 2010	17	5	1
May 2010	18	1	3
Jun 2010	10	3	2
Jul 2010	9	9	6
Aug 2010	2	11	5
Sep 2010	7	3	2
Oct 2010	9	4	1
Nov 2010	12	1	1
Dec 2010	8	0	3
Jan 2011	10	3	2
Feb 2011	12	6	6
Mar 2011	20	2	6
Apr 2011	20	2	1
May 2011	10	1	0
Jun 2011	9	0	1
Jul 2011	8	2	4
Aug 2011	10	0	2
Sep 2011	11	3	4
Oct 2011	19	1	4
Nov 2011	20	8	3
Dec 2011	17	10	12
Jan 2012	16	10	4
Feb 2012	24	8	4
Mar 2012	14	11	5
Apr 2012	15	7	11
May 2012	12	17	6
Jun 2012	15	14	4
Jul 2012	15	21	8
Aug 2012	9	21	10
Sep 2012	15	28	14
Oct 2012	35	27	24
Nov 2012	20	43	13
Dec 2012	14	20	10
Jan 2013	26	27	11
Feb 2013	10	48	13
Mar 2013	18	34	8
Apr 2013	18	26	8
May 2013	16	16	12
Jun 2013	9	21	10
Jul 2013	5	14	6
Aug 2013	12	10	7
Sep 2013	13	7	5
Oct 2013	14	12	5
Nov 2013	12	8	9
Dec 2013	6	11	7
Jan 2014	7	17	8
Feb 2014	4	14	8
Mar 2014	9	22	9
Apr 2014	12	21	10
May 2014	16	38	20
Jun 2014	5	28	9
Jul 2014	11	20	4
Aug 2014	8	20	6
Sep 2014	6	60	18
Oct 2014	7	21	4
Nov 2014	6	11	3
Dec 2014	6	5	3
Jan 2015	22	30	0
Feb 2015	5	10	5
Mar 2015	14	39	8
Apr 2015	13	34	8
May 2015	10	36	12
Jun 2015	8	54	9
Jul 2015	12	29	3
Aug 2015	11	42	9
Sep 2015	17	26	1
Oct 2015	14	24	7
Nov 2015	9	53	17
Dec 2015	15	9	9
Jan 2016	19	36	9
Feb 2016	10	14	7
Mar 2016	7	14	4
Apr 2016	4	33	4
May 2016	5	20	7
Jun 2016	5	20	11
Jul 2016	12	29	9
Aug 2016	9	23	10
Sep 2016	12	13	4
Oct 2016	12	24	5
Nov 2016	14	26	3
Dec 2016	11	12	5
Jan 2017	7	9	3
Feb 2017	5	15	4
Mar 2017	5	10	2
Apr 2017	2	8	0
May 2017	5	10	4
Jun 2017	4	9	1
Jul 2017	18	15	2
Aug 2017	12	12	1
Sep 2017	17	15	2
Oct 2017	21	17	3
Nov 2017	29	19	5
Dec 2017	20	10	3
Jan 2018	24	16	3
Feb 2018	26	20	6
Mar 2018	12	10	3
Apr 2018	14	10	0
May 2018	19	13	3
Jun 2018	22	18	5
Jul 2018	14	12	10
Aug 2018	27	27	7
Sep 2018	22	20	8
Oct 2018	7	7	3
Nov 2018	20	18	4
Dec 2018	15	13	5
Jan 2019	10	10	3
Feb 2019	11	11	4
Mar 2019	19	17	6
Apr 2019	13	13	6
May 2019	9	9	5
Jun 2019	5	5	4
Jul 2019	4	4	1
Aug 2019	9	7	4
Sep 2019	6	6	0
Oct 2019	22	20	4
Nov 2019	10	8	6
Dec 2019	10	10	6
Jan 2020	17	17	2
Feb 2020	9	7	12
Mar 2020	7	7	5
Apr 2020	11	11	3
May 2020	15	15	6
Jun 2020	8	8	2
Jul 2020	11	9	4
Aug 2020	15	9	3
Sep 2020	22	12	2
Oct 2020	12	8	4
Nov 2020	22	16	5
Dec 2020	15	13	4
Jan 2021	19	16	2
Feb 2021	13	11	2
Mar 2021	13	13	2
Apr 2021	25	25	2
May 2021	10	10	0
Jun 2021	6	6	2
Jul 2021	10	10	3
Aug 2021	12	12	3
Sep 2021	13	13	1
Oct 2021	12	12	6
Nov 2021	15	13	6
Dec 2021	11	11	6
Jan 2022	9	7	5
Feb 2022	10	6	9
Mar 2022	36	32	10
Apr 2022	21	20	5
May 2022	39	39	8
Jun 2022	16	16	1
Jul 2022	20	19	2
Aug 2022	28	28	4
Sep 2022	24	19	2
Oct 2022	38	30	7
Nov 2022	17	17	4
Dec 2022	14	14	1
Jan 2023	28	24	2
Feb 2023	31	27	2
Total	3612	4413	1755

Log in using your username and password

Main menu

Log in using your username and password

You are here

Online download statistics by month:

Online download statistics by month: March 2000 to March 2023

Read the full text or download the PDF:

Log in using your username and password