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Vasculitic neuropathy in a patient with inactive treated lepromatous leprosy
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  1. J R C Bowena,
  2. A C McDougallb,
  3. J H Morrisc,
  4. S B Lucasd,
  5. M Donaghya
  1. aDepartment of Clinical Neurology, Radcliffe Infirmary, Oxford, UK, bDepartment of Dermatology, cDepartment of Neuropathology, dDepartment of Histopathology, St Thomas' Hospital, London, UK
  1. Dr M Donaghy, Department of Clinical Neurology, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK

Abstract

A 46 year old Asian male with previously treated lepromatous leprosy developed a stepwise multifocal sensory disturbance 25 years later. Neurophysiology demonstrated marked deterioration from previous studies. Sural nerve biopsy disclosed a vasculitic process superimposed on inactive lepromatous leprosy. Immunocytochemical stains for mycobacterial antigen showed deposits within nerve and vessel walls. A delayed vasculitic neuropathy precipitated by persisting mycobacterial antigen is proposed.

  • vasculitic neuropathy
  • lepromatous leprosy

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