Article Text

Inverse relation between Braak stage and cerebrovascular pathology in Alzheimer predominant dementia
  1. Ludwig Boltzmann Institute of Clinical Neurobiology, PKH/B-Building; Baumgartner Hoehe 1; A-1140 Vienna,

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Goulding et al 1 carried out a preliminary retrospective postmortem analysis of 25 patients (13 men, 12 women, mean age 80.7 years) with the clinical diagnosis of Alzheimer-type dementia (only one with suspected multi-infarct dementia) and a 36.4% frequency of the ApoEε4 allele. Eighteen brains (89%) with neuritic Braak stage ⩽4 had either additional cerebrovascular lesions (n=14), or Lewy bodies (n=l), or both (n=6), with a significant inverse correlation between cerebrovascular lesions and Braak stage. Forty eight per cent of the brains showed small focal infarcts, and only 20% disclosed “pure” Alzheimer's disease pathology. No association between the ε4 allele and any pathological variable was found. Based on …

    View Full Text