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Injections of botulinum toxin A into the salivary glands improve sialorrhoea in amyotrophic lateral sclerosis
  1. R Giessa,
  2. M Naumanna,
  3. E Wernerb,
  4. R Riemannc,
  5. M Becka,
  6. I Pulsa,
  7. C Reinersb,
  8. K V Toykaa
  1. aDepartment of Neurology, Bayerische Julius-Maximilians- University, Josef Schneider Straβe 11, 97080 Wuerzburg, Germany, bDepartment of Nuclear Medicine, cDepartment of Otorhinolaryngology
  1. Dr M Naumannnaumann{at}mail.uni-wuerzburg.de

Abstract

Sialorrhoea is a socially disabling problem in bulbar amyotrophic lateral sclerosis (ALS). Botulinum toxin A (BoNT/A) was injected into the salivary glands in five patients with bulbar ALS and sialorrhoea. The effect of BoNT/A was measured by the number of paper handkerchiefs used each day and by salivary gland scintigraphy. BoNT/A ameliorated sialorrhoea and quality of life without major adverse effects. BoNT/A may be a relatively safe and effective treatment for sialorrhoea in selected patients.

  • ALS
  • sialorrhoea
  • salivary glands
  • botulinum toxin A

https://doi.org/10.1136/jnnp.69.1.121

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