Article Text

Download PDFPDF
Diffusion tensor imaging can detect and quantify corticospinal tract degeneration after stroke
  1. David J Werring,
  2. Ahmed T Toosy,
  3. Christopher A Clark,
  4. Geoffrey JM Parker,
  5. Gareth J Barker,
  6. David H Miller,
  7. Alan J Thompson
  1. NMR Research Unit, Institute of Neurology, Queen Square, London WC1N 3BG, UK
  1. Professor AJ Thompsona.thompson{at}


Diffusion tensor imaging (DTI) fully characterises water molecule mobility in vivo, allowing an exploration of fibre tract integrity and orientation in the human brain. Using DTI this study demonstrates reduced fibre coherence (anisotropy) associated with cerebral infarction and in the corticospinal tract remote from the lesion, in five patients 2 to 6 months after ischaemic stroke. The study highlights the potential of DTI to detect and monitor the structural degeneration of fibre pathways, which may provide a better understanding of the pattern of clinical evolution after stroke.

  • magnetic resonance imaging
  • diffusion tensor
  • stroke
  • pathophysiology

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.