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What contributes to quality of life in patients with Parkinson's disease?
  1. Anette Schrag,
  2. Marjan Jahanshahi,
  3. Niall Quinn
  1. Department of Neurology, Institute of Neurology, Queen Square, London WC1N 3BG, UK
  1. Professor NP Quinn n.quinn{at}


OBJECTIVE To identify the factors that determine quality of life (QoL) in patients with idiopathic Parkinson's disease in a population based sample. Quality of life (QoL) is increasingly recognised as a critical measure in health care as it incorporates the patients' own perspective of their health.

METHODS All patients with Parkinson's disease seen in a population based study on the prevalence of parkinsonism were asked to complete a disease-specific QoL questionnaire (PDQ-39) and the Beck depression inventory. A structured questionnaire interview and a complete neurological examination, including the Hoehn and Yahr scale, the Schwab and England disability scale, the motor part of the unified Parkinson's disease rating scale (UPDRS part III), and the mini mental state examination were performed by a neurologist on the same day.

RESULTS The response rate was 78%. The factor most closely associated with QoL was the presence of depression, but disability, as measured by the Schwab and England scale, postural instability, and cognitive impairment additionally contributed to poor QoL. Although the UPDRS part III correlated significantly with QoL scores, it did not contribute substantially to predicting their variance once depression, disability, and postural instability had been taken into account. In addition, patients with akinetic rigid Parkinson's disease had worse QoL scores than those with tremor dominant disease, mainly due to impairment of axial features.

CONCLUSION Depression, disability, postural instability, and cognitive impairment have the greatest influence on QoL in Parkinson's disease. The improvement of these features should therefore become an important target in the treatment of the disease.

  • quality of life
  • Parkinson's disease

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Treatment of Parkinson's disease is primarily aimed at improving motor function. However, especially in advanced stages, Parkinson's disease is often complicated by additional problems such as treatment related complications, falls, depression, and dementia,1 which may have much greater impact on the patients' quality of life (QoL) than the cardinal features of Parkinson's disease. A disease specific QoL instrument for use with patients with Parkinson's disease, the PDQ-39, has been shown to have good reliability, validity, responsiveness, and reproducibility,2-4 and is now used in many trials to assess effectiveness of treatment.5 Its disease specificity and the single summary index offer the opportunity to assess the overall impact of illness, and it is easy to interpret.6 We used this instrument to determine which disease related factors, such as presence of specific symptoms, degree of impairment, disability, depression, or cognitive impairment, are the most relevant for quality of life in a population based sample of patients with Parkinson's disease.

Patients and methods

All patients with Parkinson's disease seen in a population based study on the prevalence of parkinsonism were included. The methods of case ascertainment and diagnosis have been described in detail elsewhere.7 Briefly, the records of 15 general practices in the area of London covering a population of 121 608 were screened for patients with a suspicion of Parkinson's disease or parkinsonism, for patients with tremor with onset after the age of 50, and for patients who had ever received antiparkinsonian drugs. As the health care system in the United Kingdom is organised locally the population of a general practice is representative of the surrounding area. In addition, the general practitioner acts as a “gatekeeper” of the Health Service, so that patients are only referred to specialists by their general practitioners. Patients who agreed to participate had a complete neurological examination and a structured questionnaire interview which were performed by a movement disorders specialist (AS). Parkinson's disease was diagnosed according to the United Kingdom brain bank criteria8 with the exception that patients with an isolated Babinski's sign but otherwise typical Parkinson's disease were not excluded. Patients with atypical parkinsonian disorders, drug induced parkinsonism, vascular pseudoparkinsonism, and those with parkinsonism after dementia were excluded from this study. The assessment included the Hoehn and Yahr scale,9 the Schwab and England disability scale,10 the motor part of the unified Parkinson's disease rating scale (UPDRS)11 and the mini mental state examination (MMSE).12 In addition, patients were questioned about the presence or absence of symptoms and signs associated with Parkinson's disease, such as hallucinations, falls, gait impairment, motor fluctuations or dyskinesias, incontinence, orthostatic symptoms, insomnia, pain, speech, or swallowing impairment, or a family history of Parkinson's disease. They were also asked which single symptom had been predominant at onset and whether they were unemployed or had retired early due to having Parkinson's disease. At the time of the diagnostic visit, all patients were also given the PDQ-39, a disease specific, 39 item questionnaire on QoL in Parkinson's disease,2 the Beck depression inventory (BDI),13 as well as two other QoL instruments (EQ-5D and short form-36)14 15 which are not the subject of this paper, and asked to complete and return them within the next 2 weeks in a stamped, addressed envelope.


The PDQ-39 comprises 39 questions, each with five different answer options (never, occasionally, sometimes, often, or always). Eight subscores (mobility, activities of daily living, emotional wellbeing, stigma, social support, cognition, communication, and bodily discomfort), and one summary index, can be calculated (maximum score 100 indicating worst level of problem). The BDI is a widely used 21 item depression inventory with answer options from 0–3 and a maximum score of 63. The cut off score for moderate to severe depression used was 17 (18 or more indicates moderate to severe depression).16 Cognitive impairment was measured using the mini mental examination scale12 with a cut off score of 24 or less.


Summary scores as well as the subdimensions of the PDQ-39 were calculated according to the scoring algorithm.17 The akinesia score of the UPDRS was calculated as the sum of item 19 and 23 to 26 of the UPDRS for both sides, the score of axial features from items 27 to 30, and the tremor score from items 20 and 21 for both sides. The tremor dominant subtype of Parkinson's disease was defined as patients with a ratio of tremor to bradykinesia score (bradykinesia rigidity and postural instability subscores from the UPDRS motor scale and history) of 0.5 or more, and the akinetic rigid subtype as patients with a ratio of<0.5. Socioeconomic groups were determined according to the classification of occupations and coding index with socioeconomic group 1 representing the highest and group 5 the lowest socioeconomic class.18

Mean values were compared by the Mann-Whitney test, and Spearman rank correlation coefficients were calculated to assess the direction and magnitude of association between variables. Stepwise multiple regression analysis was used to determine the factors that best accounted for variance in QoL scores. Due to the number of different comparisons, statistical significance was only accepted at p<0.005.


Among all patients seen (n=202), 124 were classified as having probable Parkinson's disease. The response rate was 78% (97/124 questionnaires). There was no significant difference between responders and non-responders for age, disease duration, sex, Hoehn and Yahr stage, and Schwab and England score (p>0.05). Five questionnaires were returned with incomplete data (<50% of the QoL instrument), and were not used for further analysis. The characteristics of the responders are given in table 1.

Table 1

Patient characteristics (n=92)


Patients with high levels of depression (with BDI scores>17), a mini mental state score of 24 or less (out of 30),12postural instability on examination (as described in the UPDRS), and a history of falls or of gait difficulties had significantly worse PDQ-39 summary index scores than patients without these features (table 2). QoL scores of patients with the akinetic rigid subtype of Parkinson's disease were also worse than those with tremor dominant disease. This difference could not be explained by older age or longer disease duration, as age and disease duration were similar between those with tremor dominant and those with akinetic rigid Parkinson's disease. The difference of QoL scores between those with and those without a history of hallucinations just failed to reach significance (p=0.026; table 2). No difference in PDQ-39 scores was found between men and women and between patients with or without a poor (subjectively<50%) initial or current response to antiparkinsonian medication. A history of dyskinesias or fluctuations, incontinence, orthostatic symptoms, insomnia, pain, speech or swallowing impairment, a family history of Parkinson's disease, and symptom at onset had no significant impact on QoL scores. There was also no difference between those who were unemployed or had retired early due to the disease and those who were not, those with disease onset before or after the age of 50, and those with current age older than 60 or 70.

Table 2

Clinical features associated with significantly impaired quality of life scores


The PDQ-39 summary index correlated significantly and positively (r=0.68, p<0.001) with depression as measured by the BDI score and negatively with disability as measured by the Schwab and England scale (r=−0.66, p<0.001). Significant correlations were also obtained with disease severity as measured by the Hoehn and Yahr scale (r=0.6, p<0.001), the UPDRS motor subscore of axial features (r=0.57, p<0.001), the total UPDRS motor score (r=0.41, p<0.001), and the MMSE (r=−0.32, p<0.001). Correlations with duration of disease and age were not significant (r=0.18, p=0.19 andr=0.14, p=0.25, respectively), and akinesia score (r=0.3, p=0.028) and socioeconomic groups (r=0.25, p=0.023) just failed to correlate significantly with QoL.


To determine which factors contributed most to QoL scores, we performed a stepwise linear regression, entering age, disease duration, and all factors that were shown to have an impact on QoL scores (see previous sections) into the regression in a stepwise fashion (table 3). The most important predictive factor was the BDI depression score, followed by disability as measured by the Schwab and England score, which together accounted for 64% of the variance of QoL scores. Additional contributing factors were postural instability and cognitive impairment as measured by the MMSE score, which accounted for a further 8% of the variance of QoL scores. To account for some of the overlap of contents in quality of life and disability measures, as well as the Schwab and England with Hoehn and Yahr scores (r=−0.74, p<0.0001), we performed a separate analysis excluding Schwab and England scores from the analysis. Depression, Hoehn and Yahr, and MMSE scores then accounted for 59% of the variance of quality of life scores.

Table 3

Results of stepwise multiple regression analysis of PDQ-39 scores


In this study, the strongest predictor of QoL in Parkinson's disease was the presence of depression, as measured by the Beck depression inventory score. This correlation of QoL with depression has also been found in other studies on QoL in Parkinson's disease, accounting for up to 60% of impairment of PDQ-39 scores,19 20 but also in other chronic diseases where depression has been found to have a major influence on QoL scores.21 It could be argued that the PDQ-39 and the BDI measure the same content and hence have a strong correlation. However, the PDQ-39 comprises eight different dimensions of which depression features in only one. In addition, the results were similar when the two other administered, generic, QoL instruments (EQ-5D and short form-36) were used. The results of the EQ-5D will be reported in detail elsewhere. Using the same variables in the regression analysis together with a history of hallucinations, 64% of the variance of the generic QoL measure EQ-5D was possible. When a regression analysis was performed on the physical summary score of the short form-36, 33% of its variance was predicted by the Schwab and England score and postural instability alone, whereas 23% of the variance of the mental summary score of the SF-36 was predicted by the BDI alone. No other factors contributed to prediction of the variance in these two generic QoL scores. When considering the results of all these regression analyses, it should be noted that the direction of causality between QoL, depression, and disability is difficult to establish with correlational methods. Nevertheless, the association of Parkinson's disease with depression is well known, but treatment of depression in the disease is often insufficient.22 The results of this study highlight the need to diagnose and treat depression in Parkinson's disease more effectively to improve the patients' QoL.

As expected, QoL was also strongly related to disability as measured by the Schwab and England scores. However, there is some overlap in the content of QoL and disability scales, and, additionally, disability scores also strongly correlated with disease severity, as measured by the Hoehn and Yahr scale (r=−0.74, p<0.0001). When two variables are very strongly associated—for example, with correlations in the order of 0.8 or 0.9—collinearity is a potential source of error in regression analysis. Although the correlation between the measures of disability and disease severity was only 0.74, we nevertheless performed a separate regression analysis excluding disability as a variable. The results of this analysis were similar but, as might be expected, disease severity replaced disability as a predictor of QoL. In addition, postural instability, which is one of the key criteria for staging in the Hoehn and Yahr scale and was therefore associated with higher Hoehn and Yahr scores (p<0.005), no longer additionally contributed to predicting QoL scores. Depression and MMSE scores, on the other hand, continued to contribute to the prediction of QoL scores. Scores on the MMSE were not strongly associated with depression (r=−0.15, NS) or Hoehn and Yahr scores (r=−0.27, p<0.05). As cognitive impairment does not respond to, and can be aggravated by, medication that improves mobility, it presents a major problem in the management of Parkinson's disease, and has been shown to be the primary reason for nursing home placement.23 Our results further confirm the importance of cognitive impairment in determining QoL.

The correlation of QoL scores with measures of disease severity and disability has been shown previously2 3 20 24 and is not surprising. However, the motor part of the UPDRS, which is the primary outcome measure for most treatment trials in Parkinson's disease, correlated less strongly with QoL scores. This scale, by contrast with the Hoehn and Yahr scale, involves a detailed assessment of parkinsonian features, comprising items of speech, hypomimia, tremor, and rigidity in addition to bradykinesia and axial features such as postural instability and gait. However, these subscores did not have a significant influence on QoL scores. As a consequence, the Hoehn and Yahr scale, which reflects predominantly axial features, correlated more strongly with QoL scores than the motor part of the UPDRS. This suggests that the Hoehn and Yahr scale may be a more sensitive measure than the motor part of the UPDRS to evaluate the impact that severity of disease has on the patients' everyday life.

Tremor and rigidity scores did not correlate with QoL scores. Gait problems and limb akinesia, on the other hand, were associated with worse QoL, although not contributing further to its prediction once disease severity was accounted for. Similarly, Petoet al 2 found that self reported slowness was significantly related to seven out of the eight subdimensions of the PDQ-39, whereas self reported tremor and rigidity were much less markedly correlated with the PDQ-39 subdimensions. We also found that patients with the akinetic rigid subtype of PD (which incorporates greater impairment of axial features) had worse QoL scores than those with the tremor dominant subtype of Parkinson's disease. In studies assessing subtypes of parkinsonism, tremor dominant disease has usually been found to have a better prognosis than the akinetic rigid subtype, with a slower rate of progression of motor symptoms.25 26 Our findings of a better QoL in tremor dominant Parkinson's disease further support this differentiation. Symptoms at onset, on the other hand, did not significantly affect QoL scores. However, information on type of symptom at onset was collected by patient report, which has a low reliability.27

A history of hallucinations on antiparkinsonian treatment just failed to be significantly associated with worse QoL scores, and a history of fluctuations of motor response to medication or presence of dyskinesias were also not associated with poor QoL. However, these results may be due to the relatively few patients with these complications which, if present, were usually not severe in this population based sample.

In accordance with our findings, Karlsen et al 24 also found that depression and disability are important predictors of QoL in Parkinson's disease. However, by contrast with our study, postural instability did not correlate as strongly with QoL, whereas insomnia, which did not predict QoL in our study, was an important influential factor in their study. This difference is likely to arise from their use of the Nottingham Health Profile (NHP), which is a generic rather than a disease specific instrument, and therefore does not address specific problems that arise in Parkinson's disease. It has been used to assess QoL in patients with Parkinson's disease in a large study of Sinemet CR,28 but its validity in patients with Parkinson's disease has not been formally tested. In addition, it is highly skewed at the severe end of ill health, and will not detect subtle impairments. The section on sleep is larger in the NHP than in the disease specific PDQ-39, and insomnia is therefore more likely to correlate with NHP scores. The disease specific PDQ-39 used in this study, on the other hand, is based on problems reported by patients with Parkinson's disease2 and some correlations of this instrument with symptoms of Parkinson's disease therefore result from its development. Our findings are, however, enhanced by the result that when two other, generic, QoL instruments were used, the same factors were predictive of the variance of QoL scores. The prediction of variance of QoL scores was similar when the EQ-5D was used as a dependent variable, whereas it was lower when the separate physical and mental summary scores of the SF-36 were used. The SF-36 has been shown also in other disorders to have a low sensitivity to discriminate between patient differences in overall QoL.29 30 Although high correlations of PDQ-39 scores may be partly due to the design of this disease specific instrument, the similar albeit less significant results with the two generic instruments therefore support the validity of our findings.

The QoL is a complex concept to which many factors other than health contribute. This complexity of the concept of QoL is also the main limitation of this study, as many variables that potentially contribute to QoL, such as social support and individual coping strategies, were not directly measured. Also, we have no information on variables such as the cultural context of the patients' lives or availability of healthcare resources, which may have great potential for modifying the impact of the disease on the QoL in Parkinson's disease. However, lower socioeconomic group just failed to be significantly associated with worse QoL scores.

On the positive side, we think that the results of this study can be generalised to a wider population of patients with Parkinson's disease, as the patients were seen in a population based epidemiological study with a high response rate (84%). Also, the results are clinically relevant in this patient group due to the disease specificity of the instrument used.

We conclude that QoL in idiopathic Parkinson's disease is primarily determined by depression, disability, disease severity (particularly related to axial features), and cognitive impairment. Patients with the akinetic rigid subtype have worse QoL scores than those with tremor dominant disease. The motor part of the UPDRS, although the primary outcome measure for clinical trials with antiparkinsonian medication, did not contribute significantly to QoL in Parkinson's disease, and additional emphasis on other disease features should therefore gain greater importance in the treatment of the disease.


This study was made possible by a grant from SmithKline Beecham Pharmaceuticals. MJ is funded by the Wellcome Trust.


View Abstract

Supplementary materials

    What contributes to quality of life in patients with Parkinson's disease?
    Anette Schrag, Marjan Jahanshahi, Niall Quinn
    J Neurol Neurosurg Psychiatry 2000;69:308-12

    Table 2
    The values of PDQ-39 in depressed and non-depressed patients should read 49.8 (21.4) and 23.6 (14.3) and not as published. The error is regretted.

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